Research Training in Hematology

血液学研究培训

• 批准号: 7435738
• 负责人: JOHN Patrick SHEEHAN
• 金额: $ 39.02万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7435738
• 关键词: Hematology; Research Training

Description (provided by applicant): The current training program brings together twenty faculty members from a total of nine Departments on campus to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal of this grant is to train a mixture of M.D. and Ph.D. scientists with outstanding potential to develop a sustained, independent research program in these fields. Two predoctoral positions are requested to take advantage of the outstanding pool of M.D.- Ph.D. candidates and the long tradition of strong graduate programs at the University of Wisconsin. Fellows or residents in the Clinical Investigator track from the participating clinical Departments (Medicine, Pediatrics, Pathology, and Surgery) and Ph.D. trainees from the participating basic science departments (Anatomy, Biochemistry, Biostatistics, Microbiology, and Pharmacology) will be selected for the four postdoctoral positions. The faculty are a stable and interactive group that clusters in three major interest groups: basic and clinical aspects of hemostasis/inflammation, hematologic malignancies, and human stem cells/bone marrow transplantation. The faculty have broad expertise in both basic science and clinical sciences, including experimental approaches in gene arrays and genomics, transcriptional and post-transcriptional gene expression, protein structural analysis, proteomics, cell biology, hematopoetic and endothelial cell culture, murine animal models, primate and human embryonic stems cells, and bone marrow transplantation. There is a strong emphasis oh providing the multidisciplinary training required to pursue translational research opportunities, and the formal training of clinical investigators. Our training program takes advantage of the Clinical Investigator Preparatory Program (K30 grant) at the University of Wisconsin to provide didactic training in clinical trial design and biostatistics for candidates pursuing translational research projects. The program has an excellent record of retaining trainees in academic medicine. Of our eight predoctoral candidates, six continue in their Ph.D. degree program, and two have completed their degree and obtained excellent post-doctoral positions at outside institutions (Harvard, Mayo). Eleven of our postdoctoral candidates have now completed their research training. Six are successful academic researchers, two are active researchers in biotechnology companies (including a Director of Research), and one is in medical school. We have successfully recruited four under-represented minorities to the grant, and fully half of our appointees are women. The large pool of qualified candidates, outstanding mentorship abilities of our trainers, excellent core facilities, institutional commitment, and broad range of scientific expertise fosters multidisciplinary approaches that will ensure successful careers in science for our trainees.

描述（由申请人提供）：当前的培训计划汇集了校园中总共九个部门的二十名教职员工，以关注对血液学和人类疾病的两个广泛重要性的领域：血管生物学和干细胞生物学/血液学恶性肿瘤。这笔赠款的主要目标是培训医学博士学位和博士学位的混合。在这些领域开发持续的独立研究计划的杰出潜力的科学家。要求两个占主导地位的职位，以利用M.D.-Ph.D.的未偿还库。候选人和威斯康星大学强大的研究生课程的悠久传统。来自参与临床部门（医学，儿科，病理学和手术）和博士学位的临床研究者轨道的研究员或居民。参与基础科学部门的学员（解剖学，生物化学，生物化学，微生物学和药理学）将被选为四个博士后职位。该教师是一个稳定且互动的群体，该群体将三个主要兴趣群体聚集：止血/炎症的基本和临床方面，血液学恶性肿瘤以及人类干细胞/骨髓移植。该教师在基础科学和临床科学方面都具有广泛的专业知识，包括基因阵列和基因组学的实验方法，转录和转录后基因表达，蛋白质结构分析，蛋白质组学，蛋白质组学，细胞生物学，造血和内皮细胞培养，鼠类动物模型，灵长类动物和人类胚胎茎细胞和人类的细胞和骨骼MaroW trambow and bone Marow and bonemow。非常重视OH，提供了追求转化研究机会所需的多学科培训，以及对临床研究人员的正式培训。我们的培训计划利用了威斯康星大学的临床研究人员预备计划（K30 Grant），为追求翻译研究项目的候选人提供临床试验设计和生物统计学的教学培训。该计划在保留学术医学的学员方面有很好的记录。在我们的八位候选人中，有六名继续获得博士学位。学位课程和两个已经完成了学位，并在外部机构（哈佛大学，梅奥）获得了出色的博士后职位。我们的博士后候选人中有11位已经完成了他们的研究培训。六名是成功的学术研究人员，其中两名是生物技术公司（包括研究主管）的活跃研究人员，其中一名正在医学院。我们已经成功地招募了四个代表性的少数群体，并完全招募了我们一半的任命人是妇女。大量合格的候选人，我们教练的出色指导能力，出色的核心设施，机构承诺以及广泛的科学专业知识促进了多学科的方法，以确保我们的学员在科学方面的成功职业。