Research Training In Hematology

描述（由申请人提供）：我们的培训计划汇集了来自八个部门的二十名教师，专注于血液学和人类疾病的两个广泛重要领域：血管生物学和干细胞生物学/血液恶性肿瘤。主要目标是培养医学博士。和博士科学家在多学科环境中进行持续、独立的血液学研究。两个博士前的职位要求，将从优秀的博士池填补。还有医学博士博士学生在完善的研究生课程在威斯康星州（UW）的大学。要求四个博士后职位，以培养参与临床（医学，儿科，病理学和外科）和基础科学（生物医学工程，生物分子化学，细胞和再生医学，肿瘤学）部门的研究轨道候选人。高度互动的培训教师集群分为三个兴趣小组：血管生物学，血液恶性肿瘤和干细胞/移植。血管生物学方面的专业知识包括细胞和分子止血、细胞外基质生物学、血管发生/血管生成、炎症的细胞机制、血管和趋化性建模、临床血友病和血栓形成。血液恶性肿瘤/干细胞生物学由一个杰出的胚胎干细胞研究小组领导。专长包括胚胎和诱导多能干细胞、白血病干细胞、造血的表观遗传调控、信号通路、骨髓瘤动物模型、淋巴瘤临床试验、肿瘤免疫治疗以及血管和恶性疾病中的临床干细胞应用。培训机会涵盖基础和临床研究;包括基因组学、蛋白质组学、高通量筛选、微流体、鼠疾病模型和干细胞移植方面的尖端技术。重点放在临床研究人员的转化研究和多学科培训上。华盛顿大学临床转化研究所提供临床调查，职业发展和指导专业知识的教学和学位课程。我们的学员在建立研究事业方面有着出色的记录。九名博士预科生现已完成博士学位。度三个是学术研究人员，一个是工业科学家，一个是大学化学讲师，一个是博士后科学家，三个是医学博士。博士完成医学院/研究生培训的学生。19名博士后已完成培训.三位是非常成功的副教授，六位是助理教授，两位是学术科学家，四位是工业科学家。大量合格的候选人，我们的培训师，机构的承诺，以及广泛的科学专业知识的优秀指导记录都有助于我们的学员在科学事业的成功。

DESCRIPTION (provided by applicant): Our training program brings together twenty faculty members from eight Departments to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal is to train M.D. and Ph.D. scientists in a multi- disciplinary environment to do sustained, independent research in hematology. Two predoctoral positions are requested to that will be filled from outstanding pool of Ph.D. and M.D.-Ph.D. students in the well-established graduate programs at the University of Wisconsin (UW). Four postdoctoral positions are requested to train research track candidates from participating clinical (Medicine, Pediatrics, Pathology, and Surgery) and basic science (Biomedical Engineering, Biomolecular Chemistry, Cell and Regenerative Medicine, Oncology) departments. The highly interactive training faculty cluster into three interest groups: vascular biology, hematologic malignancies, and stem cells/transplantation. Expertise in vascular biology includes cellular and molecular hemostasis, extracellular matrix biology, vasculogenesis/angiogenesis, cellular mechanisms of inflammation, modeling of vessels and chemotaxis, clinical hemophilia and thrombophilia. Hematologic malignancy/stem cell biology is led by a prominent group of embryonic stem cell investigators. Expertise includes embryonic and induced pluripotent stem cells, leukemic stem cells, epigenetic regulation of hematopoiesis, signaling pathways, animal models in myeloma, clinical trials in lymphoma, tumor immunotherapy, and clinical stem cell applications in vascular and malignant disease. Training opportunities span basic and clinical investigation; including cutting edge technologies in genomics, proteomics, high throughput screening, microfluidics, murine disease models, and stem cell transplantation. A strong emphasis is placed on translational research and multidisciplinary training of clinical investigators. The UW Institute for Clinical an Translational Research offers didactic and degree programs in clinical investigation, career development, and mentoring expertise. Our trainees have an excellent record of establishing research careers. Nine predoctoral appointees have now completed their Ph.D. degrees. Three are academic researchers, one is an industry scientist, one is a college chemistry instructor, one is postdoctoral scientist, and three are M.D.-Ph.D. students completing medical school/postgraduate training. Nineteen post- doctoral appointees have now completed training. Three are highly successful associate professors, six are assistant professors, two are academic scientists, and four are industry scientists. The large pool of qualified candidates, outstanding mentorship record of our trainers, institutional commitment, and broad range of scientific expertise all contribute to successful careers in science for our trainees.