Research Training In Hematology

血液学研究培训

• 批准号: 9000727
• 负责人: JOHN Patrick SHEEHAN
• 金额: $ 41.94万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9000727
• 关键词: Hematology; Research Training

DESCRIPTION (provided by applicant): Our training program brings together twenty faculty members from eight Departments to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal is to train M.D. and Ph.D. scientists in a multi- disciplinary environment to do sustained, independent research in hematology. Two predoctoral positions are requested to that will be filled from outstanding pool of Ph.D. and M.D.-Ph.D. students in the well-established graduate programs at the University of Wisconsin (UW). Four postdoctoral positions are requested to train research track candidates from participating clinical (Medicine, Pediatrics, Pathology, and Surgery) and basic science (Biomedical Engineering, Biomolecular Chemistry, Cell and Regenerative Medicine, Oncology) departments. The highly interactive training faculty cluster into three interest groups: vascular biology, hematologic malignancies, and stem cells/transplantation. Expertise in vascular biology includes cellular and molecular hemostasis, extracellular matrix biology, vasculogenesis/angiogenesis, cellular mechanisms of inflammation, modeling of vessels and chemotaxis, clinical hemophilia and thrombophilia. Hematologic malignancy/stem cell biology is led by a prominent group of embryonic stem cell investigators. Expertise includes embryonic and induced pluripotent stem cells, leukemic stem cells, epigenetic regulation of hematopoiesis, signaling pathways, animal models in myeloma, clinical trials in lymphoma, tumor immunotherapy, and clinical stem cell applications in vascular and malignant disease. Training opportunities span basic and clinical investigation; including cutting edge technologies in genomics, proteomics, high throughput screening, microfluidics, murine disease models, and stem cell transplantation. A strong emphasis is placed on translational research and multidisciplinary training of clinical investigators. The UW Institute for Clinical an Translational Research offers didactic and degree programs in clinical investigation, career development, and mentoring expertise. Our trainees have an excellent record of establishing research careers. Nine predoctoral appointees have now completed their Ph.D. degrees. Three are academic researchers, one is an industry scientist, one is a college chemistry instructor, one is postdoctoral scientist, and three are M.D.-Ph.D. students completing medical school/postgraduate training. Nineteen post- doctoral appointees have now completed training. Three are highly successful associate professors, six are assistant professors, two are academic scientists, and four are industry scientists. The large pool of qualified candidates, outstanding mentorship record of our trainers, institutional commitment, and broad range of scientific expertise all contribute to successful careers in science for our trainees.

描述（由申请人提供）：我们的培训计划汇集了来自8个部门的20名教员，专注于两个对血液学和人类疾病具有广泛重要性的领域：血管生物学和干细胞生物学/血液恶性肿瘤。主要目标是培养医学博士和博士科学家在一个多学科的环境中做持续的，独立的血液学研究。2个博士预科职位将从优秀的博士和医学博士中填补。威斯康星大学（UW）完善的研究生课程的学生。招收临床（医学、儿科、病理、外科）和基础科学（生物医学工程、生物分子化学、细胞与再生医学、肿瘤）学科博士后4名。互动性强的培训师资分为三个兴趣小组：血管生物学、血液恶性肿瘤和干细胞/移植。血管生物学的专业知识包括细胞和分子止血，细胞外基质生物学，血管发生/血管生成，炎症的细胞机制，血管建模和趋化性，临床血友病和亲血栓症。血液恶性肿瘤/干细胞生物学是由一群杰出的胚胎干细胞研究者领导的。专长包括胚胎和诱导多能干细胞、白血病干细胞、造血的表观遗传调控、信号通路、骨髓瘤动物模型、淋巴瘤临床试验、肿瘤免疫治疗以及干细胞在血管和恶性疾病中的临床应用。培训机会涵盖基础和临床研究；包括基因组学、蛋白质组学、高通量筛选、微流体、小鼠疾病模型和干细胞移植等前沿技术。重点放在转化研究和临床研究人员的多学科培训上。华盛顿大学临床与转化研究所提供临床调查、职业发展和专业指导方面的教学和学位课程。我们的学员在建立研究事业方面有着出色的记录。9名博士前受聘人员已完成博士学位。3名学术研究员，1名行业科学家，1名大学化学讲师，1名博士后科学家，3名医学博士。完成医学院/研究生培训的学生。已有19名博士后完成培养。其中3人是非常成功的副教授，6人是助理教授，2人是学术科学家，4人是行业科学家。大量合格的候选人，我们的培训师出色的指导记录，机构承诺和广泛的科学专业知识都有助于我们的学员在科学领域取得成功。