Research Training In Hematology

描述(由申请者提供)：我们的培训计划汇集了来自八个系的二十名教员，专注于对血液学和人类疾病具有广泛重要性的两个领域：血管生物学和干细胞生物学/血液恶性肿瘤。主要目标是在多学科环境中培训医学博士和博士科学家，以便在血液学方面进行持续的、独立的研究。需要两个博士前职位，将从威斯康星大学(UW)著名研究生项目的优秀博士和医学博士研究生中填补。需要四个博士后职位，以培训参与临床(医学、儿科、病理学和外科)和基础科学(生物医学工程、生物分子化学、细胞和再生医学、肿瘤学)的研究跟踪候选人。高度互动的培训人员分为三个兴趣小组：血管生物学、血液系统恶性肿瘤和干细胞/移植。血管生物学的专业知识包括细胞和分子止血、细胞外基质生物学、血管生成/血管生成、炎症的细胞机制、血管建模和趋化作用、临床血友病和血栓形成。血液恶性肿瘤/干细胞生物学是由一群杰出的胚胎干细胞研究人员领导的。专长包括胚胎和诱导多能干细胞、白血病干细胞、造血的表观遗传调控、信号通路、骨髓瘤动物模型、淋巴瘤临床试验、肿瘤免疫治疗以及干细胞在血管和恶性疾病中的临床应用。培训机会涵盖基础和临床研究；包括基因组学、蛋白质组学、高通量筛查、微流体、小鼠疾病模型和干细胞移植方面的尖端技术。非常重视转化性研究和临床研究人员的多学科培训。威斯康星大学临床与翻译研究所提供临床调查、职业发展和专业指导方面的教学和学位课程。我们的学员在建立研究事业方面有着出色的记录。九名博士前任命者现已完成博士学位。三名是学术研究人员，一名是工业科学家，一名是大学化学讲师，一名是博士后科学家，三名是完成医学院/研究生培训的医学博士研究生。19名博士后任命人员现已完成培训。三位是非常成功的副教授，六位是助理教授，两位是学术科学家，四位是行业科学家。大量合格的候选人，我们培训师出色的指导记录，机构的承诺，以及广泛的科学专业知识，这些都有助于我们的学员在科学领域取得成功。

DESCRIPTION (provided by applicant): Our training program brings together twenty faculty members from eight Departments to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal is to train M.D. and Ph.D. scientists in a multi- disciplinary environment to do sustained, independent research in hematology. Two predoctoral positions are requested to that will be filled from outstanding pool of Ph.D. and M.D.-Ph.D. students in the well-established graduate programs at the University of Wisconsin (UW). Four postdoctoral positions are requested to train research track candidates from participating clinical (Medicine, Pediatrics, Pathology, and Surgery) and basic science (Biomedical Engineering, Biomolecular Chemistry, Cell and Regenerative Medicine, Oncology) departments. The highly interactive training faculty cluster into three interest groups: vascular biology, hematologic malignancies, and stem cells/transplantation. Expertise in vascular biology includes cellular and molecular hemostasis, extracellular matrix biology, vasculogenesis/angiogenesis, cellular mechanisms of inflammation, modeling of vessels and chemotaxis, clinical hemophilia and thrombophilia. Hematologic malignancy/stem cell biology is led by a prominent group of embryonic stem cell investigators. Expertise includes embryonic and induced pluripotent stem cells, leukemic stem cells, epigenetic regulation of hematopoiesis, signaling pathways, animal models in myeloma, clinical trials in lymphoma, tumor immunotherapy, and clinical stem cell applications in vascular and malignant disease. Training opportunities span basic and clinical investigation; including cutting edge technologies in genomics, proteomics, high throughput screening, microfluidics, murine disease models, and stem cell transplantation. A strong emphasis is placed on translational research and multidisciplinary training of clinical investigators. The UW Institute for Clinical an Translational Research offers didactic and degree programs in clinical investigation, career development, and mentoring expertise. Our trainees have an excellent record of establishing research careers. Nine predoctoral appointees have now completed their Ph.D. degrees. Three are academic researchers, one is an industry scientist, one is a college chemistry instructor, one is postdoctoral scientist, and three are M.D.-Ph.D. students completing medical school/postgraduate training. Nineteen post- doctoral appointees have now completed training. Three are highly successful associate professors, six are assistant professors, two are academic scientists, and four are industry scientists. The large pool of qualified candidates, outstanding mentorship record of our trainers, institutional commitment, and broad range of scientific expertise all contribute to successful careers in science for our trainees.