Research Training in Hematology

血液学研究培训

• 批准号: 8323921
• 负责人: JOHN Patrick SHEEHAN
• 金额: $ 5.28万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8323921
• 关键词: Hematology; Research Training

The current training program brings together twenty faculty members from a total of nine Departments on campus to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal of this grant is to train a mixture of M.D. and Ph.D. scientists with outstanding potential to develop a sustained, independent research program in these fields. Two predoctoral positions are requested to take advantage of the outstanding pool of M.D.- Ph.D. candidates and the long tradition of strong graduate programs at the University of Wisconsin. Fellows or residents in the Clinical Investigator track from the participating clinical Departments (Medicine, Pediatrics, Pathology, and Surgery) and Ph.D. trainees from the participating basic science departments (Anatomy, Biochemistry, Biostatistics, Microbiology, and Pharmacology) will be selected for the four postdoctoral positions. The faculty are a stable and interactive group that clusters in three major interest groups: basic and clinical aspects of hemostasis/inflammation, hematologic malignancies, and human stem cells/bone marrow transplantation. The faculty have broad expertise in both basic science and clinical sciences, including experimental approaches in gene arrays and genomics, transcriptional and post-transcriptional gene expression, protein structural analysis, proteomics, cell biology, hematopoetic and endothelial cell culture, murine animal models, primate and human embryonic stems cells, and bone marrow transplantation. There is a strong emphasis oh providing the multidisciplinary training required to pursue translational research opportunities, and the formal training of clinical investigators. Our training program takes advantage of the Clinical Investigator Preparatory Program (K30 grant) at the University of Wisconsin to provide didactic training in clinical trial design and biostatistics for candidates pursuing translational research projects. The program has an excellent record of retaining trainees in academic medicine. Of our eight predoctoral candiidates, six continue in their Ph.D. degree program, and two have completed their degree and obtained excellent post-doctoral positions at outside institutions (Harvard, Mayo). Eleven of our postdoctoral candidates have now completed their research training. Six are successful academic researchers, two are active researchers in biotechnology companies (including a Director of Research), and one is in medical school. We have successfully recruited four under-represented minorities to the grant, and fully half of our appointees are women. The large pool of qualified candidates, outstanding mentorship abilities of our trainers, excellent core facilities, institutional commitment, and broad range of scientific expertise fosters multidisciplinary approaches that will ensure successful careers in science for our trainees.

当前的培训计划汇集了来自总共九个部门的二十名教职员工 校园专注于血液学和人类疾病的两个广泛重要性的领域：血管生物学 和干细胞生物学/血液学恶性肿瘤。这笔赠款的主要目标是培训医学博士的混合。 和博士具有开发持续的独立研究计划的杰出潜力的科学家 这些字段。要求两个占主导地位的职位，以利用M.D.-的未偿还库。 博士候选人和威斯康星大学强大的研究生课程的悠久传统。研究员 或参与临床部门的临床研究者轨道的居民（医学，儿科， 病理学和手术）和博士学位。参与基础科学部门的学员（解剖学， 将为四个博士后选择生物化学，生物统计学，微生物学和药理学） 位置。该教师是一个稳定且互动的群体，该群体将三个主要兴趣群体分类：基本 止血/炎症，血液学恶性肿瘤和人干细胞/骨骼的临床方面 骨髓移植。该教师在基础科学和临床科学方面都有广泛的专业知识， 包括基因阵列和基因组学，转录和转录后的实验方法 基因表达，蛋白质结构分析，蛋白质组学，细胞生物学，造血细胞和内皮细胞 培养，鼠类动物模型，灵长类动物和人类胚胎干细胞以及骨髓移植。 强烈重视哦，提供了进行翻译所需的多学科培训 研究机会以及临床研究人员的正式培训。我们的培训计划需要 威斯康星大学的临床研究人员预备计划（K30 Grant）的优势 为候选人提供临床试验设计和生物统计学的教学培训 项目。该计划在保留学术医学的学员方面有很好的记录。我们的八个 候选人念珠菌冠军，六个继续获得博士学位。学位课程，两个已经完成学位 并在外部机构（哈佛，梅奥）获得了出色的博士后职位。我们十个 博士后候选人现在已经完成了他们的研究培训。六个是成功的学术 研究人员，两个是生物技术公司（包括研究主管）的活跃研究人员， 一个在医学院。我们已经成功地招募了四个代表不足的少数群体，并 我们一半的任命是女性。大量合格的候选人，出色的指导 我们的培训师的能力，出色的核心设施，机构承诺和广泛的科学范围 专业知识促进了多学科方法，这些方法将确保我们的学员在科学领域的成功职业。