Research Training in Hematology

目前的培训计划汇集了来自9个系的20名教职员工 校园将专注于血液学和人类疾病两个广泛重要的领域：血管生物学 干细胞生物学/血液系统恶性肿瘤。这笔赠款的主要目标是培养医学博士的混合体。 以及具有杰出潜力的博士科学家，他们将在 这些领域。要求提供两个博士前职位，以利用尚未毕业的医学博士- 博士候选人和威斯康星大学强大的研究生课程的悠久传统。研究员 或来自参与临床科室(内科、儿科、 病理学和外科)和来自参与的基础科学系(解剖学、 生物化学、生物统计学、微生物学和药理学)将被选为四名博士后 各就各位。教职员工是一个稳定和互动的群体，聚集在三个主要的兴趣群体中：基本 止血/炎症、恶性血液病和人类干细胞/骨的临床方面 骨髓移植。教职员工在基础科学和临床科学方面都有广泛的专业知识， 包括基因阵列和基因组学、转录和转录后的实验方法 基因表达、蛋白质结构分析、蛋白质组学、细胞生物学、造血和内皮细胞 培养，小鼠动物模型，灵长类和人类胚胎干细胞，以及骨髓移植。 我们非常重视提供从事翻译工作所需的多学科培训 研究机会，以及临床研究人员的正规培训。我们的培训计划需要 威斯康星大学临床研究人员预备计划(K30助学金)的优势 为从事翻译研究的候选人提供临床试验设计和生物统计学方面的教学培训 项目。该项目在留住学术医学实习生方面有着良好的记录。我们八个人中的一个 博士前候选人中，六人继续攻读博士学位，两人已完成学位 并在外部机构(哈佛大学、梅奥分校)获得了优秀的博士后职位。我们的11个人 博士后候选人现在已经完成了他们的研究培训。六位是成功的学术人士 研究人员，两名是生物技术公司的活跃研究人员(包括一名研究主任)，以及 其中一人在读医学院。我们已经成功地招募了四名代表不足的少数族裔参加赠款，以及 我们任命的人中有整整一半是女性。大量合格的候选人，杰出的导师 我们培训人员的能力、出色的核心设施、机构承诺和广泛的科学研究 专业知识促进多学科方法，确保我们的受训人员在科学领域取得成功。

The current training program brings together twenty faculty members from a total of nine Departments on campus to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal of this grant is to train a mixture of M.D. and Ph.D. scientists with outstanding potential to develop a sustained, independent research program in these fields. Two predoctoral positions are requested to take advantage of the outstanding pool of M.D.- Ph.D. candidates and the long tradition of strong graduate programs at the University of Wisconsin. Fellows or residents in the Clinical Investigator track from the participating clinical Departments (Medicine, Pediatrics, Pathology, and Surgery) and Ph.D. trainees from the participating basic science departments (Anatomy, Biochemistry, Biostatistics, Microbiology, and Pharmacology) will be selected for the four postdoctoral positions. The faculty are a stable and interactive group that clusters in three major interest groups: basic and clinical aspects of hemostasis/inflammation, hematologic malignancies, and human stem cells/bone marrow transplantation. The faculty have broad expertise in both basic science and clinical sciences, including experimental approaches in gene arrays and genomics, transcriptional and post-transcriptional gene expression, protein structural analysis, proteomics, cell biology, hematopoetic and endothelial cell culture, murine animal models, primate and human embryonic stems cells, and bone marrow transplantation. There is a strong emphasis oh providing the multidisciplinary training required to pursue translational research opportunities, and the formal training of clinical investigators. Our training program takes advantage of the Clinical Investigator Preparatory Program (K30 grant) at the University of Wisconsin to provide didactic training in clinical trial design and biostatistics for candidates pursuing translational research projects. The program has an excellent record of retaining trainees in academic medicine. Of our eight predoctoral candiidates, six continue in their Ph.D. degree program, and two have completed their degree and obtained excellent post-doctoral positions at outside institutions (Harvard, Mayo). Eleven of our postdoctoral candidates have now completed their research training. Six are successful academic researchers, two are active researchers in biotechnology companies (including a Director of Research), and one is in medical school. We have successfully recruited four under-represented minorities to the grant, and fully half of our appointees are women. The large pool of qualified candidates, outstanding mentorship abilities of our trainers, excellent core facilities, institutional commitment, and broad range of scientific expertise fosters multidisciplinary approaches that will ensure successful careers in science for our trainees.