Neurobehavioral Teratology Society: Symposium on Pesticides and Metals

描述（由申请人提供） 这是一项资助将于2008年6月29日至7月2日在加利福尼亚州蒙特雷举行的神经行为畸形学学会（NBTS）年会上举行的为期1.5天的研讨会的提案。NBTS将与两个“姐妹”学会，畸形学学会（TS）和畸形学信息专家组织（奥蒂斯）联合举行会议，其成员也将有机会参加研讨会。 研讨会将重点关注农药和金属对神经发育的影响，并将汇集一些研究这些暴露的领先流行病学家和实验室动物科学家。 其中一个分两部分的会议将重点介绍来自前瞻性出生队列研究的新流行病学研究，这些研究审查了农业农药暴露、城市室内农药暴露以及包括铅、汞和锰在内的金属暴露。已确认的发言者包括布伦达·埃斯肯纳齐博士、弗吉尼亚·劳博士、玛丽·沃尔夫博士、伊莱恩·福斯特曼博士、罗伯特·赖特博士、金·迪特里希博士、杰里·赖特博士和埃尔瓦·赫兹-皮乔托博士。 第二次会议将强调在动物模型中处理类似暴露的平行研究。确认的演讲者包括爱德华·莱文博士、芭芭拉·斯特鲁普博士、黛博拉·赖斯博士、杰森·理查森博士和蒂姆·马赫博士。 研讨会的目的不仅是传达农药和金属的最新研究成果，而且是弥合人类和动物研究观点之间的差距。 研讨会是及时的，因为人类早期接触农药的神经发育风险才刚刚开始被人们所了解。 同样，关注与金属暴露相关的新问题，包括汞在自闭症谱系障碍中的潜在作用，早期铅暴露在后来的反社会行为中的作用，以及基因-环境相互作用在金属神经毒性中的作用，是非常及时的。 将专注于相同暴露和发育结果的流行病学家和动物研究人员聚集在一起，将为这些研究团体提供更广阔的视角，并为研究合作的发展创造肥沃的土壤。 大多数发言者不是NBTS、TS或奥蒂斯的成员，也不经常参加这次会议。 这次研讨会将为他们提供一个机会，向新的观众介绍他们的研究，并获得他们的投入。 研讨会的论文集将作为三篇同行评议文章的系列发表在《神经毒理学和畸形学》杂志上。 每一次会议都将总结、综合和讨论三次会议中的一次会议上提出的关于以下问题的研究结果：（一）农药;（二）金属;（三）农药和金属接触的动物模型。 由于将提出的大部分研究重点是代表性不足的少数群体人口，该协会将在附近的大学校园，特别是少数群体学生比例高的大学校园广泛宣传，并将免除任何有兴趣参加研讨会的少数群体学生的会议注册费。

DESCRIPTION (provided by applicant) This is a proposal for funding to support a 1.5 day symposium that would be held at the annual meeting of the Neurobehavioral Teratology Society (NBTS), June 29-July 2, 2008 in Monterey, CA. NBTS will meet jointly with two "sister" societies, the Teratology Society (TS) and the Organization of Teratology Information Specialists (OTIS) whose members will also have the opportunity to attend the symposium. The symposium will focus on neurodevelopmental effects of pesticides and metals and will bring together some of the leading epidemiologists and laboratory animal scientists studying these exposures. One two-part session would feature new epidemiological research from prospective birth cohort studies examining agricultural pesticide exposures, urban indoor pesticide exposures, and exposures to metals including lead, mercury and manganese. Confirmed speakers include Dr. Brenda Eskenazi, Dr. Virginia Rauh, Dr. Mary Wolff, Dr. Elaine Faustman, Dr. Robert Wright, Dr. Kim Dietrich, Dr. Jerry Reiter and Dr. Irva Hertz- Picciotto. A second session would highlight parallel research addressing similar exposures in animal models. Confirmed speakers include Dr. Edward Levin, Dr. Barbara Strupp, Dr. Deborah Rice, Dr. Jason Richardson and Dr. Tim Maher. The goal of the proposed symposium is not only to convey the newest research findings on pesticides and metals, but also to bridge the gap between human and animal research perspectives. The symposium is timely because the neurodevelopmental risks from early pesticide exposure in human populations are just beginning to become known. Similarly, the focus on new issues related to metal exposures including the potential role of mercury in autism spectrum disorders, the role of early lead exposure in later antisocial behavior, and the role of gene-environment interactions in metal neurotoxicity is very timely. Bringing together epidemiologists and animal researchers focused on the same exposures and developmental outcomes will provide each of these research communities with a broader perspective and create fertile ground for the development of research collaborations. A majority of the speakers are not members of NBTS, TS or OTIS and do not regularly attend this meeting. This symposium will provide an opportunity for them to present their research to a new audience and get their input. Proceedings of the symposium will be published in the journal Neurotoxicology and Teratology as a series of three peer-reviewed articles. Each will summarize, integrate and discuss the findings presented in one of the three sessions on: (i) pesticides, (ii) metals and (iii) animal models of pesticide and metal exposure. Since much of the research that will be presented focuses on under-represented minority populations the Society will advertise widely at nearby college campuses, particularly those with high percentages of minority students and will waive conference registration fees for any minority students interested in attending the symposium.