Graduate Training at the Chemistry Biology Interface

描述(由申请者提供)：本提案要求为化学/生物学接口(CBI)的一项倡议提供资金。该计划于1998年在密歇根大学启动，旨在为化学专业的学生提供熟悉生物科学的机会，并为生物科学专业的学生提供熟悉化学的机会。到目前为止，这个项目已经招收了11名高素质的学生，所有这些学生都表现得很好。密歇根州立大学CBI项目的学生将注册化学博士项目(CHEM)、与巴尔的摩马里兰大学(UMB)联合生物化学博士项目(BIOC)或分子和细胞生物学博士项目(MOCB)。这些学生的毕业论文导师可以来自密歇根大学的三个系(化学和生物化学、生物科学或化学和生化工程)和UMB(生物化学和分子生物学系)的一个系。通过让每个学生(1)完成生物实验室和化学实验室的轮换；(2)参加两个学科的高级课程；(3)参加名为“化学/生物界面的问题”的年度课程；(4)参加CBI的年度研讨会；以及(5)参加CBI的研讨会和会议，确保跨学科培训。参与研究的教师的研究兴趣广泛，从光化学到生物分析化学、合成化学和酶学，再到结构生物学、细胞生物学和免疫学。目前该专业学生的研究领域包括：核糖体蛋白S3、S4和S5在翻译中的作用；小分子热休克蛋白HSP 17.7的分子生物学和质谱学表征；不同核酸构象和序列的分离和检测；时间分辨线性二色性光谱的应用；3-氧代-5-类固醇异构酶对5-雄烯-3，17-二酮异构化的活化焓和活化熵；高分辨率FT-ICR质谱法表征HIV-1位点内的蛋白质-RNA复合体；生物活性硫代化合物体外微透析的高级应用；MHC-II类多肽负载内源性肿瘤抗原的机制研究HIV-2基因组识别的核磁共振研究。学员的定期会议将确保他们接触到CBI的各种主题。

DESCRIPTION (provided by applicant): This proposal requests funding for an initiative at the Chemistry/Biology Interface (CBI). This program was started at UMBC in 1998 to provide an opportunity for chemistry students to become conversant in the biological sciences and students in the biological sciences to become familiar with chemistry. To date, eleven highly qualified students have been recruited to this program, and all of these students are performing very well. Students in the UMBC CBI program will be registered in either the Ph.D. program in chemistry (CHEM), the joint biochemistry Ph.D. program (BIOC) with the University of Maryland, Baltimore (UMB) or the Ph.D. program in Molecular and Cell Biology (MOCB). Dissertation mentors for these students can come from three UMBC departments (Chemistry & Biochemistry, Biological Sciences or Chemical & Biochemical Engineering) and one department at UMB (Department of Biochemistry & Molecular Biology). Cross-disciplinary training will be ensured by having each student (1) complete a rotation in both a biologically-oriented laboratory and a chemically-oriented laboratory; (2) take an advanced course in both disciplines; (3) enroll in a yearly course entitled "Issues at the Chemistry/Biology Interface;" (4) participate in an annual CBI Workshop; and (5) attend seminars and meetings with a focus on interdisciplinary work at the CBI. Research interests of the participating faculty span a wide variety of areas from photochemistry, through bioanalytical chemistry, synthetic chemistry and enzymology to structural biology, cell biology and immunology. Research areas of current students in the program are: The Role of Ribosomal Proteins S3, S4, and S5 in Translation; Characterization of Small Heat Shock Protein Hsp 17.7 via Molecular Biology and Mass Spectrometry Analysis; Separation and Detection of Varying Nucleic Acid Conformations and Sequences; Applications of Time-Resolved Linear Dichroism Spectroscopy; Activation Enthalpies and Entropies for Isomerization of 5-Androstene-3,17-dione by 3-Oxo-?5-steroid Isomerase; Characterization of Protein-RNA Complexes within the HIV-1 ?-Site by High Resolution FT-ICR Mass Spectrometry; Advanced Applications of In Vitro Microdialysis for Bioactive Thiocompounds; Mechanisms of MHC class II peptide loading in endogenous tumor antigen presentation; NMR Studies of HIV-2 Genome Recognition. Regular meetings of the trainees will ensure that they are exposed to a wide variety of topics at the CBI.