Predoctoral Training at the Interface Chemistry and Biology

项目总结/摘要 博士前化学/生物学界面培训计划（CBITP）的广泛使命是教育， 培养和发展不同背景的早期职业科学家成为思想领袖，榜样和 化学/生物学界面的创新者，为人类带来更大的利益。的总体目标 该计划旨在培养将对化学生物科学做出重大贡献的科学家， 持续影响，最终造福社会。在第二年的支持培训期间（5名学生） 和3（5名学生）的整体CBITP，学生将：1）发展现代广泛的背景知识 化学生物学研究; 2）发展化学中使用的详细方法的强大背景知识 生物学领域; 3）展示化学生物学专业领域的先进知识，包括关键 评价分子结构、功能、（生物）合成、反应性和在基础细胞/ 生物生理学; 4）设计，执行和传达原创，高质量，严格（稳健）的控制 和统计分析），并在严格审查以前的科学研究 化学生物学知识; 5）表达自我效能和专业精神，以驾驭生物医学 科学职业前景;和6）发展专业的口头和书面沟通技巧。作为大型制药公司， 内部研发（R&D）工作减少，内部就业机会增加 生物技术/生物制药行业有所增长。根据定义，新生物制药企业的成立涉及 化学和生物学的结合。在这个界面上培训学生的基本原理不仅 帮助提供生物技术/生物制药部门的劳动力，但也将培养下一代教师 和企业家促进科学技术创新，保持美国在这些领域的领导地位 在世界舞台该计划利用了非常深刻和多样的化学，生物和生物学。 耶鲁大学的生物医学科学申请者群体，以及耶鲁大学的非凡研究实力， 相关教师我们已经建立了严格的CBITP核心课程与新的和密集的半学分 模块，这使学生在匹配指令和课程与他们的更灵活的 教育和研究需要。我们还建立了各种CBITP特定的实践 研究（例如，高通量筛选、基因组学、蛋白质组学等）和职业（例如，实习与 生物制药，生物科学的替代职业等）研讨会，除了化学生物学研讨会和 会议，以促进整体学生和计划的成功。为了评估疗效，培训结果， 和职业成果出现从我们现有的和新的方案活动，除了探索 根据学员的经验，我们将采用数据驱动的混合方法进行持续改进。 总的来说，我们建议将我们成功的20年CBITP现代化为新的下一代CBITP。

Project Summary/Abstract The broad mission of the predoctoral Chemistry/Biology Interface Training Program (CBITP) is to educate, train, and develop early-career scientists of diverse backgrounds to be thought leaders, role models and innovators at the Chemistry/Biology Interface for the greater benefit of humanity. The overall objective of the program is to train scientists who will make strong contributions to the chemical biological sciences leading to a sustained impact, ultimately benefitting society. During their supported training period in years 2 (5 students) and 3 (5 students) of the overall CBITP, students will: 1) Develop broad background knowledge of modern chemical biology research; 2) Develop strong background knowledge of detailed methods used in the chemical biology field; 3) Demonstrate advanced knowledge in specialized areas of chemical biology, including critical evaluation of molecular structure, function, (bio)synthesis, reactivity, and application in basic cellular/ organismal physiology; 4) Design, perform and communicate original, high-quality, rigorous (robust controls and statistical analysis), and ethically-conducted research upon critically examining previous scientific knowledge in chemical biology; 5) Express self-efficacy and professionalism to navigate the biomedical science career landscape; and 6) Develop professional oral and written communication skills. As large pharma internal Research & Development (R&D) efforts have decreased, job opportunities within the growing biotech/biopharma sector have increased. The founding of new biopharma ventures, by definition, involves a combination of chemistry and biology. The rationale for the training of students at this interface will not only help supply the workforce in the biotech/biopharma sector but will also produce the next generation of faculty and entrepreneurs to promote science and technology innovations and maintain U.S. leadership in these areas on the world stage. The program takes advantage of the very deep and diverse chemical, biological, and biomedical sciences applicant pool at Yale University as well as the extraordinary research strengths of the associated faculty. We have established a rigorous CBITP core curriculum with new and intensive half credit modules, which allows the students more flexibility in matching instruction and coursework with their educational and research needs. We have also established an assortment of CBITP-specific hands-on research (e.g., high-throughput screening, genomics, proteomics, etc) and career (e.g., internships with biopharma, alternative careers in bioscience, etc) workshops in addition to chemical biology symposia and conferences to promote overall student and program successes. To evaluate the efficacy, training outcomes, and career outcomes emerging from our existing and new programmatic activities, in addition to exploring the experiences of our trainees, we will employ a data-driven mixed-methods approach for continuous refinement. Collectively, we propose to modernize our successful 20-year CBITP for this new, next generation CBITP.