Predoctoral Training at the Interface Chemistry and Biology

界面化学与生物学博士前培训

• 批准号: 10628150
• 负责人: Jason Michael Crawford
• 金额: $ 53.05万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628150
• 关键词: Biology; Chemistry; Training; pre-doctoral

Project Summary/Abstract The broad mission of the predoctoral Chemistry/Biology Interface Training Program (CBITP) is to educate, train, and develop early-career scientists of diverse backgrounds to be thought leaders, role models and innovators at the Chemistry/Biology Interface for the greater benefit of humanity. The overall objective of the program is to train scientists who will make strong contributions to the chemical biological sciences leading to a sustained impact, ultimately benefitting society. During their supported training period in years 2 (5 students) and 3 (5 students) of the overall CBITP, students will: 1) Develop broad background knowledge of modern chemical biology research; 2) Develop strong background knowledge of detailed methods used in the chemical biology field; 3) Demonstrate advanced knowledge in specialized areas of chemical biology, including critical evaluation of molecular structure, function, (bio)synthesis, reactivity, and application in basic cellular/ organismal physiology; 4) Design, perform and communicate original, high-quality, rigorous (robust controls and statistical analysis), and ethically-conducted research upon critically examining previous scientific knowledge in chemical biology; 5) Express self-efficacy and professionalism to navigate the biomedical science career landscape; and 6) Develop professional oral and written communication skills. As large pharma internal Research & Development (R&D) efforts have decreased, job opportunities within the growing biotech/biopharma sector have increased. The founding of new biopharma ventures, by definition, involves a combination of chemistry and biology. The rationale for the training of students at this interface will not only help supply the workforce in the biotech/biopharma sector but will also produce the next generation of faculty and entrepreneurs to promote science and technology innovations and maintain U.S. leadership in these areas on the world stage. The program takes advantage of the very deep and diverse chemical, biological, and biomedical sciences applicant pool at Yale University as well as the extraordinary research strengths of the associated faculty. We have established a rigorous CBITP core curriculum with new and intensive half credit modules, which allows the students more flexibility in matching instruction and coursework with their educational and research needs. We have also established an assortment of CBITP-specific hands-on research (e.g., high-throughput screening, genomics, proteomics, etc) and career (e.g., internships with biopharma, alternative careers in bioscience, etc) workshops in addition to chemical biology symposia and conferences to promote overall student and program successes. To evaluate the efficacy, training outcomes, and career outcomes emerging from our existing and new programmatic activities, in addition to exploring the experiences of our trainees, we will employ a data-driven mixed-methods approach for continuous refinement. Collectively, we propose to modernize our successful 20-year CBITP for this new, next generation CBITP.

项目摘要/摘要 博士前化学/生物学接口培训计划(CBITP)的广泛使命是教育， 培养和发展具有不同背景的早期职业科学家，使其成为思想领袖、榜样和 化学/生物界面的创新者，为人类带来更大的利益。《公约》的总体目标 该计划是培养对化学生物科学做出重大贡献的科学家，从而导致 持续的影响，最终造福社会。在二年级的辅导性培训期间(5名学生) 和3名(5名学生)整个CBITP，学生将：1)发展广泛的背景知识，现代 化学生物学研究；2)对化学中使用的详细方法有扎实的背景知识 生物领域；3)具备化学生物学专业领域的先进知识，包括关键知识 评价分子结构、功能、(生物)合成、反应活性及其在基础细胞研究中的应用 生物体生理学；4)设计、执行和传达原创的、高质量的、严格的(强大的控制 和统计分析)，以及在批判性地检查以前的科学研究的基础上进行的伦理研究 具备化学生物学知识；5)具有良好的自我效能感和专业精神，能驾驭生物医学 科学的职业前景；6)培养专业的口头和书面沟通技能。作为大型制药公司 内部研发(R&D)努力减少，内部就业机会不断增加 生物技术/生物制药板块有所增加。根据定义，创建新的生物制药企业涉及到 化学和生物的结合。在这个界面上培训学生的理由不仅是 帮助提供生物技术/生物制药部门的劳动力，但也将培养下一代教师 和企业家推动科技创新，保持美国在这些领域的领导地位 在世界舞台上。该计划利用了非常深入和多样化的化学、生物和 耶鲁大学生物医学科学申请者人才库，以及 联席教员。我们已经建立了严格的CBITP核心课程，新的和密集的半学分 模块，允许学生更灵活地将教学和课程作业与他们的 教育和研究需求。我们还建立了一系列针对CBITP的实际操作 研究(例如，高通量筛选、基因组学、蛋白质组学等)和职业(例如，在 生物制药、生物科学等领域的替代职业)除了化学生物学研讨会和 会议，以促进学生和项目的整体成功。评估疗效、培训结果、 以及从我们现有和新的方案活动中产生的职业成果，除了探索 根据学员的经验，我们将采用数据驱动的混合方法进行持续改进。 总而言之，我们建议对我们成功的20年CBITP进行现代化改造，以实现这一新的下一代CBITP。