Graduate Training at the Chemistry Biology Interface

本计划书为化学-生物学界面的续期申请 在马里兰州，巴尔的摩CO（UMBC）的大学研究生课程。这个项目是在UMBC开始的 1998年，由大学单独资助，直到2004年7月首次授予。该计划的启动是为了 为化学、生物化学和生物学学生提供跨学科培训的机会。迄今 十三博士除了另外19名博士生外，学生 从大学获得了更多的津贴。UMBC CBI计划的学生是 四个博士学位课程;化学，生物学，分子和细胞生物学和联合生物化学 该计划由UMBC化学系和生物化学与分子生物学系运行 生物学在马里兰州巴尔的摩（UMB）市中心的校园。跨学科培训是 以多种方式完成，一是在实验室中进行相反学科的轮换的可能性， 相反学科的高级课程，以CHEM 715班的形式每两周举行一次会议，“问题 在化学-生物学界面”，学生们参加关于职业问题的讨论，学习 如何进行研究演讲、评论和展示各种“热门”主题领域的文献，以及 接待来访的研讨会发言人。更重要的是，自 在初始供资期间，有一个正式的培训机会，有一位相反学科的导师， 由学生的研究导师结合培训机会为每个学生设计 导师新的培训机会旨在为学生提供更有意义的体验， 除了加强他们的论文研究。目前学生的一些研究项目包括： “Novel MHC II-restricted peptides for activating breast cancer-specific CD4+ T cells”，“Protein-Protein Rob和SoxS的相互作用及其在E.大肠杆菌”、“调查 新型G蛋白偶联受体黑视素的磷酸化依赖性失活”， “表征S100 B结合到抑制p53结合的小分子”，“APE 1在 DNA糖基化酶的刺激”，“TDG和APE 1之间关系的表征”，以及 化学表征的活性代谢物的aminomethone抗癌药物。对我们的项目来说是独一无二的， CBI学生从第一年开始参加，直到他们毕业，无论他们是否在 培训补助金，从而确保持续的辅导、指导和接触跨学科科学。 相关性（参见说明）： 最近，包括NIH在内的许多资助机构已经制定了新的计划来资助跨学科的研究。 随着许多科学领域的融合，在多学科领域接受培训的学生更多 有市场，也更有可能在自己的独立职业生涯中取得成功。的基本理念 CBI计划是为优秀的研究生提供机会，体验跨学科 培训除了传统的深入研究自己的学科培训。

This proposal is a renewal application for the Chemistry-Biology Interface Graduate program at the University of Maryland, Baltimore CO (UMBC). This program was started at UMBC in 1998, and solely funded by the university until the initial award in July 2004. The program was initiated to provide opportunities for cross-disciplinary training for chemistry, biochemistry and biology students. To date thirteen Ph.D. students have been funded by the training grant in addition to another nineteen Ph.D. students that have received increased stipends from the university. Students in the UMBC CBI program are part of four Ph.D. degree programs; Chemistry, Biology, Molecular and Cellular Biology and the joint Biochemistry program run by the Chemistry department at UMBC and the Department of Biochemistry and Molecular Biology at the University of Maryland Baltimore (UMB) downtown campus. Cross-disciplinary training is accomplished in a number of ways, one, the possibility for a rotation in a laboratory in the opposite discipline, an upper level course in the opposite discipline, biweekly meetings in the form of a class CHEM 715, "Issues at the Chemistry-Biology Interface", where the students participate in discussions on career issues, learn how to give research talks, review and present literature from a wide variety of "hot" topic areas, as well as to host visiting seminar speakers. More significantly, a new feature of the program has been added since the initial funding period, a formal training opportunity with a mentor in the opposite discipline, specifically designed for each student by the student's research mentor in conjunction with the training opportunity mentor. The new training opportunity is designed to give the student a more meaningful experience in addition to enhancing their dissertation research. Some of the current students' research projects include: "Novel MHC ll-restricted peptides for activating breast cancer-specific CD4+ T cells", "Protein-Protein Interactions of Rob and SoxS and their Role in Stress Defense Response Systems in E. coli", "Investigation of phosphorylation dependent deactivation of the novel G protein coupled receptor melanopsin", "Characterizing S100B Bound to Small Molecules that Inhibit p53 Binding", "The Importance of APE1 in the Stimulation of DNA Glycosylases", "Characterization of the Relationship between TDG and APE1", and "Chemically characterizing the active metabolite of aminoflavone anticancer drugs". Unique to our program, the CBI students participate from year one until they graduate, regardless of whether or not they are on the training grant, thus insuring continual mentorship, guidance and exposure to cross-disciplinary science. RELEVANCE (See instructions): Recently many funding agencies, including NIH, have instituted new programs to fund cross-disciplinary research as many areas of science are merging. Students trained in multidisciplinary areas are more marketable and also more likely to be successful in their own independent careers. The basic philosophy of the CBI program is to provide outstanding graduate students the opportunity to experience cross-disciplinary training in addition to the traditional in-depth research training in their own discipline.