ORWH: SCOR on Sex and Gender Factors Affecting Women's Health

ORWH：SCOR 关于影响女性健康的性和性别因素

• 批准号: 7288105
• 负责人: KATHLEEN T. BRADY
• 金额: $ 86.44万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7288105
• 关键词: ORWH; SCOR; Sex; Gender; Factors

DESCRIPTION (provided by applicant): Over the last four years, the Medical University of South Carolina's (MUSC) Specialized Center of Research (SCOR) on Sex and Gender Factors Affecting Women's Health has functioned as a productive interdisciplinary research center focused on treatment and relapse in substance use disorders in women. When the MUSC SCOR was established in 2002, it filled an important gap. While MUSC had significant depth and strength in translational, interdisciplinary research in the area of substance use disorders, there was no gender-specific focus. Furthermore, the MUSC SCOR was the first women's health research initiative to be undertaken on the MUSC campus. The active, campus-wide collaborations of SCOR investigators, combined with the SCOR pilot project program have encouraged and impacted gender-based research campus-wide. During the renewal period, we propose to more closely link our scientific projects and follow up on intriguing findings from the previous funding period. Each core research project will involve the investigation of the biological basis of sex differences in drug abuse reinstatement, craving and/or relapse, and treatment implications. The overarching goals of the center will focus not only on supporting and maximizing the translational scientific collaborations of the core and pilot research projects, but also on continuing to catalyze the growth of gender-based research throughout the MUSC campus. The Specific Aims for the years 6-10 of the MUSC SCOR are: Specific Aim #1: To continue the well-established, multi-disciplinary, translational program of research focused on gender-related issues in substance use disorders at MUSC. Specific Aim #2: To provide common resources through the Administrative Core to assist investigators in increasing efficiency, maximizing scientific rigor and productivity, and collecting pilot data. Specific Aim #3: To encourage and support the growth of gender-based research throughout the MUSC campus. Specific Aim #4: To attract and mentor young investigators and new faculty in the area of research, particularly patient-oriented research, in women's health issues. Specific Aim #5: To provide a regional education and training resource for research in women's health research. Center funding through the P50 funding mechanism has allowed us to 1) carve out a unique identity on campus, bringing energy and visibility to the importance of gender-specific research, 2) bring together institutional and scientific leadership to form a single operational unit, 3) establish critical infrastructure support to allow for efficient operations, integration, and stability of resources, 4) coalesce a group of senior investigators to integrate their scientific expertise and research skills and advance gender-specific research in the substance abuse area, 5) attract and train new and junior investigators in gender-specific research, 6) support the development and testing of innovative ideas through pilot project funding, and 7) provide an impressive and supportive training environment for future basic and clinical researchers interested in gender based research. The next funding period will allow us to build on these accomplishments, expand our research program into new areas utilizing innovative techniques, enhance our outreach and dissemination efforts, and attract new investigators through the Pilot Core. Our SCOR, with a truly interdisciplinary focus on gender issues in substance use disorders, is a ready resource for inter-ORWH Center collaborations and, as such, is an asset to the ORWH program.

描述（由申请人提供）：在过去四年中，南卡罗来纳医科大学（MUSC）影响妇女健康的性别和性别因素专门研究中心（SCOR）已成为一个富有成效的跨学科研究中心，重点研究妇女药物使用障碍的治疗和复发。2002年成立的MUSC SCOR填补了一个重要的空白。虽然MUSC在物质使用障碍领域的转化和跨学科研究方面具有相当的深度和实力，但没有针对性别的重点。此外，MUSC SCOR是在MUSC校园内开展的第一个妇女健康研究倡议。SCOR研究人员在全校范围内的积极合作，加上SCOR试点项目计划，鼓励并影响了全校范围内的性别研究。在续期期间，我们建议更紧密地联系我们的科学项目，并跟进上一资助期的有趣发现。每个核心研究项目将涉及调查药物滥用恢复、渴望和/或复发的性别差异的生物学基础以及治疗影响。该中心的总体目标将不仅侧重于支持和最大限度地提高核心和试点研究项目的转化科学合作，而且还将继续促进整个MUSC校园中基于性别的研究的增长。music score 6-10年的具体目标是：