Center for Reproductive Biological Research
生殖生物学研究中心
基本信息
- 批准号:7055302
- 负责人:
- 金额:$ 173.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-04-01 至 2009-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The Center for Reproductive Biology Research has been serving the scientific community for approximately 30 years, first as a P30 Center, and more recently as a U54 SCCPRR Center. The theme chosen and approved for the renewal application is "Mechanisms Involved in Female Reproduction." The purpose of this Center will be to establish a comprehensive research and training program to investigate the molecular mechanisms governing female reproduction. This research will be accomplished by four research projects. Project I "Steroid receptor activation pathways in female reproductive behavior," will investigate the interactions of steroid hormone receptors and neurotransmitters in the regulation of female hypothalamic function. Project II "Cellular signals in ovulation and luteinization," will investigate the role of progesterone receptor and its downstream targets in ovulation and luteinization. Project IlI "Oogenesis, Spermatogenesis and Sperm-Egg Interactions," will use genetically engineered mice to investigate the role of novel genes in meiosis and fertilization. Project IV "Role of the Orphan Nuclear Receptor COUP-TF-II in Endometrial Biology," will determine the molecular regulation of human endometrial stromal cell growth and differentiation. These research projects will be supported by four Cores. The Cores chosen are the Administrative Core (Core A), the Animal Core (Core B), the Cell Culture Core (Core C) and an Integrated Microscopy Core (Core D). The Administrative Core will provide the Center with centralized management. The Animal Core will centralize the technology and resources required in the use of in vivo models. The Cell Culture Core will provide investigators with specific reagents for the culture of primary cells and cell lines, as well as the expertise required to manipulate these cells. The Integrated Microscopy Core will aid investigators in the histological, immunohistochemical and ultrastructural analysis required for the execution of their projects. The Center also will support a Pilot Project (one) for exploring new areas of research, especially those that will translate findings in model systems to clinical research. In summary, the goals contained in this application from the Baylor Center for Reproductive Biology will be oriented to understanding the molecular regulation of female reproduction and fertility, and promoting training of investigators in the field of reproductive biology
生殖生物学研究中心已经为科学界服务了大约30年,首先是P30中心,最近是U 54 SCCPRR中心。选择并批准延续申请的主题是“女性生殖机制”。“该中心的目的是建立一个全面的研究和培训计划,以调查女性生殖的分子机制。本研究将通过四个研究项目来完成。项目I“女性生殖行为中的类固醇受体激活途径”将研究类固醇激素受体和神经递质在调节女性下丘脑功能中的相互作用。项目II“排卵和黄体化的细胞信号”将研究孕酮受体及其下游靶点在排卵和黄体化中的作用。项目II“卵子发生,精子发生和精卵相互作用”,将使用基因工程小鼠来研究新基因在减数分裂和受精中的作用。项目IV“孤儿核受体COUP-TF-II在子宫内膜生物学中的作用”将确定人类子宫内膜基质细胞生长和分化的分子调控。这些研究项目将得到四个核心的支持。选择的核心是管理核心(核心A)、动物核心(核心B)、细胞培养核心(核心C)和综合显微镜核心(核心D)。行政核心将为中心提供集中管理。Animal Core将集中使用体内模型所需的技术和资源。细胞培养核心将为研究者提供用于培养原代细胞和细胞系的特定试剂,以及操作这些细胞所需的专业知识。集成显微镜核心将帮助研究人员进行执行项目所需的组织学、免疫组织化学和超微结构分析。该中心还将支持一个探索新研究领域的试点项目,特别是那些将模型系统中的发现转化为临床研究的项目。总之,贝勒生殖生物学中心的这一申请中包含的目标将致力于了解女性生殖和生育力的分子调控,并促进生殖生物学领域研究人员的培训。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BERT W O'MALLEY其他文献
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{{ truncateString('BERT W O'MALLEY', 18)}}的其他基金
Project 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythms
项目 3:共激活剂依赖性肝脏 12 小时时钟协调代谢和应激节律
- 批准号:
10421284 - 财政年份:2018
- 资助金额:
$ 173.69万 - 项目类别:
Core A (Administrative/Bioinformatics/Statistics)
核心A(管理/生物信息学/统计学)
- 批准号:
10153757 - 财政年份:2018
- 资助金额:
$ 173.69万 - 项目类别:
Nuclear receptors and their Coactivators as Mediators of Systems Metabolism
核受体及其共激活剂作为系统代谢的调节剂
- 批准号:
10153756 - 财政年份:2018
- 资助金额:
$ 173.69万 - 项目类别:
Project 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythms
项目 3:共激活剂依赖性肝脏 12 小时时钟协调代谢和应激节律
- 批准号:
10153762 - 财政年份:2018
- 资助金额:
$ 173.69万 - 项目类别:
Nuclear receptors and their Coactivators as Mediators of Systems Metabolism
核受体及其共激活剂作为系统代谢的调节剂
- 批准号:
10421277 - 财政年份:2018
- 资助金额:
$ 173.69万 - 项目类别:
Nuclear receptors and their Coactivators as Mediators of Systems Metabolism
核受体及其共激活剂作为系统代谢的调节剂
- 批准号:
9975144 - 财政年份:2018
- 资助金额:
$ 173.69万 - 项目类别:
Core A (Administrative/Bioinformatics/Statistics)
核心A(管理/生物信息学/统计学)
- 批准号:
10421278 - 财政年份:2018
- 资助金额:
$ 173.69万 - 项目类别:
The ERbeta/SRC-1 isoform complex drives endometriosis progression
ERbeta/SRC-1亚型复合物驱动子宫内膜异位症进展
- 批准号:
8823016 - 财政年份:2014
- 资助金额:
$ 173.69万 - 项目类别:
The ERbeta/SRC-1 isoform complex drives endometriosis progression
ERbeta/SRC-1亚型复合物驱动子宫内膜异位症进展
- 批准号:
9258329 - 财政年份:2014
- 资助金额:
$ 173.69万 - 项目类别:
The ERbeta/SRC-1 isoform complex drives endometriosis progression
ERbeta/SRC-1亚型复合物驱动子宫内膜异位症进展
- 批准号:
8893195 - 财政年份:2014
- 资助金额:
$ 173.69万 - 项目类别:
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埃博拉病毒感染女性生殖系统
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Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
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- 批准号:
10117836 - 财政年份:2020
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Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
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- 批准号:
10269925 - 财政年份:2020
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$ 173.69万 - 项目类别:
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- 批准号:
10461161 - 财政年份:2020
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$ 173.69万 - 项目类别:
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- 批准号:
10653357 - 财政年份:2020
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$ 173.69万 - 项目类别:
Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
宾夕法尼亚大学女性生殖系统多尺度分子图谱中心
- 批准号:
10822203 - 财政年份:2020
- 资助金额:
$ 173.69万 - 项目类别:
Cell atlas of the human female reproductive system across the lifespan
人类女性生殖系统整个生命周期的细胞图谱
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MR/S036350/1 - 财政年份:2018
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Role of USP15 in pregnancy and female reproductive system
USP15 在妊娠和女性生殖系统中的作用
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17K17919 - 财政年份:2017
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$ 173.69万 - 项目类别:
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