Center for Reproductive Biological Research

描述(由申请人提供)：生殖生物学研究中心已经为科学界服务了大约30年，最初是P30中心，最近是U54 SCCPRR中心。选择和批准续签申请的主题是“涉及女性生殖的机制”。该中心的目的将是建立一个全面的研究和培训计划，以调查控制雌性生殖的分子机制。这项研究将由四个研究项目完成。项目一“女性生殖行为中的类固醇受体激活途径”将研究类固醇激素受体和神经递质在女性下丘脑功能调节中的相互作用。项目二“排卵和黄体生成中的细胞信号”将研究孕激素受体及其下游靶点在排卵和黄体生成中的作用。伊利项目“卵子发生、精子发生和精子-卵子相互作用”将使用基因工程小鼠来研究新基因在减数分裂和受精中的作用。项目IV“孤儿核受体COUP-TF-II在子宫内膜生物学中的作用”将确定人类子宫内膜间质细胞生长和分化的分子调控。这些研究项目将得到四个核心的支持。选定的核心是行政核心(核心A)、动物核心(核心B)、细胞培养核心(核心C)和综合显微镜核心(核心D)。管理核心将为中心提供集中管理。动物核心将集中使用活体模型所需的技术和资源。细胞培养核心将为研究人员提供培养原代细胞和细胞系的特定试剂，以及操纵这些细胞所需的专业知识。集成显微镜核心将帮助研究人员进行项目执行所需的组织学、免疫组织化学和超微结构分析。该中心还将支持一个试点项目，以探索新的研究领域，特别是那些将模型系统中的发现转化为临床研究的领域。总之，贝勒生殖生物学中心的这份申请书中包含的目标将致力于了解女性生殖和生育的分子调控，并促进生殖生物学领域的研究人员的培训

DESCRIPTION (provided by applicant): The Center for Reproductive Biology Research has been serving the scientific community for approximately 30 years, first as a P30 Center, and more recently as a U54 SCCPRR Center. The theme chosen and approved for the renewal application is "Mechanisms Involved in Female Reproduction." The purpose of this Center will be to establish a comprehensive research and training program to investigate the molecular mechanisms governing female reproduction. This research will be accomplished by four research projects. Project I "Steroid receptor activation pathways in female reproductive behavior," will investigate the interactions of steroid hormone receptors and neurotransmitters in the regulation of female hypothalamic function. Project II "Cellular signals in ovulation and luteinization," will investigate the role of progesterone receptor and its downstream targets in ovulation and luteinization. Project IlI "Oogenesis, Spermatogenesis and Sperm-Egg Interactions," will use genetically engineered mice to investigate the role of novel genes in meiosis and fertilization. Project IV "Role of the Orphan Nuclear Receptor COUP-TF-II in Endometrial Biology," will determine the molecular regulation of human endometrial stromal cell growth and differentiation. These research projects will be supported by four Cores. The Cores chosen are the Administrative Core (Core A), the Animal Core (Core B), the Cell Culture Core (Core C) and an Integrated Microscopy Core (Core D). The Administrative Core will provide the Center with centralized management. The Animal Core will centralize the technology and resources required in the use of in vivo models. The Cell Culture Core will provide investigators with specific reagents for the culture of primary cells and cell lines, as well as the expertise required to manipulate these cells. The Integrated Microscopy Core will aid investigators in the histological, immunohistochemical and ultrastructural analysis required for the execution of their projects. The Center also will support a Pilot Project (one) for exploring new areas of research, especially those that will translate findings in model systems to clinical research. In summary, the goals contained in this application from the Baylor Center for Reproductive Biology will be oriented to understanding the molecular regulation of female reproduction and fertility, and promoting training of investigators in the field of reproductive biology