Translational Research in Cancer Genomic Medicine

简介（由申请人提供）：申请在加州大学欧文分校开展癌症基因组医学转化研究（TRCGM）的综合培训项目。密集的生物医学研究工作在癌症子集的临床结果方面取得了重大进展。然而，开发有用和有效的药物治疗癌症仍然是一个巨大的挑战。在过去的几年里，由于人类基因组的完成，对细胞调控途径中网络连接的理解的提高以及化学生物学的进步，通过许多学术研究机构的不懈努力，发现了大量新的潜在药物靶点。这些药物靶点有望最终产生下一代抗癌药物。

DESCRIPTION (provided by applicant): Support is requested to initiate a comprehensive training program in Translational Research in Cancer Genomic Medicine (TRCGM) at the University of California, Irvine. Intensive biomedical research efforts have yielded significant advances in clinical outcomes for a subset of cancers. However, developing useful and effective drugs for treating cancer remains a great challenge. Over the last several years, because of the completion of the human genome, the improved understanding of network connections in cellular regulatory pathways and advance in chemical biology, a plethora of new potential drug targets has been identified through the persistent work in many academic research institutions. These drug targets hold the promise of eventually resulting in the next generation of anti-cancer drugs. UCI has strong programs in basic and clinical cancer research, chemical biology, the development and use of animal models for cancer research. However, until now, no strategy has combined and leveraged these strengths of academic centers in order to train researchers who will be able to integrate basic science with all the aspects of drug development. The 18 proposed faculty were selected as the program faculty for the TRCGM because their research has an important translational component and all are interested in training future translational fellows. The program will focus on training graduate students and postdoctoral and medical fellows in cancer research areas that are highly related to translational research including target identification, chemical biology, preclinical animal models, and clinical trials. Trainees in this program will develop a thorough understanding of the steps required to translate laboratory findings into drugs that may significantly benefit patients in a clinical setting. The NIH has recognized the need for such training in its Roadmap Initiatives. The TRCGM will meet these needs and will train a new cadre of cancer researchers who are able to rapidly and effectively translate laboratory research into medicine, which will improve clinical outcomes by reducing cancer morbidity and mortality.