Translational Research in Cancer Genomic Medicine

描述(由申请者提供)：请求支持在加州大学欧文分校开展癌症基因组医学转化研究(TRCGM)的综合培训计划。密集的生物医学研究工作在癌症亚组的临床结果方面取得了重大进展。然而，开发治疗癌症的有用和有效的药物仍然是一个巨大的挑战。在过去的几年里，由于人类基因组的完成，对细胞调控通路中网络连接的深入了解，以及化学生物学的进步，通过许多学术研究机构的不懈努力，已经发现了大量新的潜在药物靶点。这些药物靶点有望最终产生下一代抗癌药物。 UCI在基础和临床癌症研究、化学生物学、癌症动物模型的开发和使用方面拥有强大的项目。然而，到目前为止，还没有任何战略结合和利用学术中心的这些优势来培养能够将基础科学与药物开发的所有方面相结合的研究人员。这18名拟议的教员被选为TRCGM的项目教员，因为他们的研究具有重要的翻译成分，而且都对培养未来的翻译研究员感兴趣。该计划将重点培训癌症研究领域的研究生、博士后和医学研究员，这些领域与翻译研究高度相关，包括靶标识别、化学生物学、临床前动物模型和临床试验。该项目的受训人员将全面了解将实验室发现转化为药物所需的步骤，这些药物可能会在临床环境中对患者产生重大好处。国家卫生研究院在其路线图倡议中认识到了这种培训的必要性。TRCGM将满足这些需求，并将培训一批新的癌症研究人员，他们能够迅速有效地将实验室研究转化为医学，这将通过降低癌症发病率和死亡率来改善临床结果。

DESCRIPTION (provided by applicant): Support is requested to initiate a comprehensive training program in Translational Research in Cancer Genomic Medicine (TRCGM) at the University of California, Irvine. Intensive biomedical research efforts have yielded significant advances in clinical outcomes for a subset of cancers. However, developing useful and effective drugs for treating cancer remains a great challenge. Over the last several years, because of the completion of the human genome, the improved understanding of network connections in cellular regulatory pathways and advance in chemical biology, a plethora of new potential drug targets has been identified through the persistent work in many academic research institutions. These drug targets hold the promise of eventually resulting in the next generation of anti-cancer drugs. UCI has strong programs in basic and clinical cancer research, chemical biology, the development and use of animal models for cancer research. However, until now, no strategy has combined and leveraged these strengths of academic centers in order to train researchers who will be able to integrate basic science with all the aspects of drug development. The 18 proposed faculty were selected as the program faculty for the TRCGM because their research has an important translational component and all are interested in training future translational fellows. The program will focus on training graduate students and postdoctoral and medical fellows in cancer research areas that are highly related to translational research including target identification, chemical biology, preclinical animal models, and clinical trials. Trainees in this program will develop a thorough understanding of the steps required to translate laboratory findings into drugs that may significantly benefit patients in a clinical setting. The NIH has recognized the need for such training in its Roadmap Initiatives. The TRCGM will meet these needs and will train a new cadre of cancer researchers who are able to rapidly and effectively translate laboratory research into medicine, which will improve clinical outcomes by reducing cancer morbidity and mortality.