COMPARISON OF DOBUTAMINE AND REGADENOSON STRESS CMR

多巴酚丁胺和瑞加诺松应激 CMR 的比较

• 批准号: 7951420
• 负责人: William Gregory Hundley
• 金额: $ 0.1万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951420
• 关键词: Asthma; Cardiovascular system; Chronic Obstructive Airway Disease; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Dobutamine; Enrollment; Funding; Grant; Guidelines; Individual; Institution; Magnetic Resonance Imaging; Motion; Patients; Perfusion; Relative (related person); Research; Research Ethics Committees; Research Personnel; Resources; Schedule; Source; Stress; Stress Tests; United States National Institutes of Health; design

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal is designed to determine the feasibility, staff effort, patient comfort, and false positive rate of implementing a MRI cardiovascular stress perfusion exam with regadenoson (Lexiscan¿?¿) relative to the results obtained during a MRI dobutamine stress wall motion exam. This project will enroll individuals that are scheduled for a dobutamine stress MRI with reactive airways disease (chronic obstructive airway disease or asthma). At our institution this represents 20 ¿?? 25% of patients that are referred for stress testing, or 1 to 2 cases per day. All potential candidates will be contacted in accordance with guidelines approved by the IRB and HIPPA regulatory accords.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该提案旨在确定使用regadenoson（Lugcan）实施MRI心血管负荷灌注检查的可行性、工作人员努力程度、患者舒适度和假阳性率。该项目将招募计划进行多巴酚丁胺负荷MRI的反应性气道疾病（慢性阻塞性气道疾病或哮喘）患者。在我们的机构，这代表20？？25%的患者被转诊进行压力测试，或每天1至2例。将根据IRB批准的指南和HIPPA监管协议联系所有潜在候选人。