METAL ACCUMULATION IN THE PRION PROTEIN DISEASE SCRAPIE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Pron蛋白疾病，如疯牛病、瘙痒病和CreutzFeldt-Jakob病，是一种神经退行性蛋白质折叠疾病，涉及大脑中自然产生的蛋白质的错误折叠。Prion蛋白的功能尚不清楚，但它被认为在铜的动态平衡中发挥作用。最近，Pron错误折叠的过程与铁、铜和锌等金属离子的结合有关；然而，人们对这些相互作用知之甚少。到目前为止，普恩病毒感染的脑组织中的金属浓度通常是通过宏观(大宗)技术来测量的，例如原子吸收或电感耦合等离子体质谱(ICP-MS)，这些技术不提供任何关于局部金属聚集的空间信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prion protein diseases, such as mad cow disease, scrapie, and Creutzfeldt-Jakob disease, are neurodegenerative protein-folding diseases that involve the misfolding of naturally occurring proteins in the brain. The function of the prion protein is not known, but it is thought to play a role in copper homeostasis. Recently, the process of prion-misfolding has been associated with the binding of metal ions such as iron, copper and zinc; yet, these interactions are poorly understood. To date, metal concentrations in prion-infected brain tissue are generally measured via macroscopic (bulk) techniques, such as atomic absorption or ICP-MS, which do not provide any spatial information on localized metal accumulation.