EARLY IMMUNE EVENTS IN CHILDHOOD ASTHMA

儿童哮喘的早期免疫事件

• 批准号: 7715644
• 负责人: LISA M MILLER
• 金额: $ 8.13万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715644
• 关键词: Childhood Asthma; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Event; Funding; Grant; Immune; Institution; Lung; Macaca mulatta; Modeling; Pulmonary Eosinophilia; Research; Research Personnel; Resources; Source; Symptoms; United States National Institutes of Health; allergic airway disease; postnatal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this project is to determine the early pulmonary mechanisms that initiate development of clinical symptoms in childhood asthma, using a rhesus monkey model of allergic airways disease. We have hypothesized that pulmonary eosinophilia is a critical first step in the initiation of allergic airways disease during postnatal development.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的主要目标是使用过敏性气道疾病的恒河猴模型来确定引发儿童哮喘临床症状发展的早期肺部机制。 我们假设肺嗜酸性粒细胞增多是出生后发育过程中过敏性气道疾病发生的关键第一步。