HUMAN NEUROBLASTOMA GLYCOPROTEINS EXPRESSING HNK-1 EPITOPE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 HNK-1表位在神经细胞中表达，在细胞黏附中发挥作用。这个表位的合成被认为是 依赖于糖基转移酶GnT-VB合成的支链糖。调节这一活动的活性 酶导致神经母细胞瘤细胞黏附、迁移和侵袭性的显著变化。身份识别 参与这些功能的糖蛋白对于了解糖的功能是至关重要的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The HNK-1 epitope is expressed in neuronal cells and functions in cell adhesion. The synthesis of this epitope is believed to be dependent on the branched glycan synthesized by the glycosyltransferase GnT-VB. Modulation of the activity of this enzyme causes significant changes in neuroblastoma cell adhesion, migration, and invasiveness. Identification of the glycoproteins involved in these functions is critical for understanding glycan function.