HUMAN NEUROBLASTOMA GLYCOPROTEINS EXPRESSING HNK-1 EPITOPE

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 HNK-1 表位在神经元细胞中表达并在细胞粘附中发挥作用。 据信该表位的合成 依赖于糖基转移酶 GnT-VB 合成的支链聚糖。 调节这种活性 酶引起神经母细胞瘤细胞粘附、迁移和侵袭的显着变化。 鉴定 参与这些功能的糖蛋白对于理解聚糖功能至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The HNK-1 epitope is expressed in neuronal cells and functions in cell adhesion. The synthesis of this epitope is believed to be dependent on the branched glycan synthesized by the glycosyltransferase GnT-VB. Modulation of the activity of this enzyme causes significant changes in neuroblastoma cell adhesion, migration, and invasiveness. Identification of the glycoproteins involved in these functions is critical for understanding glycan function.