Translational and Clinical Research on Cancer: Glycomics Applications

描述（由申请人提供）：糖组学是一个新兴领域，研究聚糖的结构和功能，有望对癌症生物标志物的发现领域产生重大影响。主要集中在日本和美国的团体开发了新技术，可以对患病人体组织和液体中的聚糖和糖肽进行全面分析，作为识别潜在癌症和其他疾病标志物的一种手段。此外，打印聚糖的微阵列可用于鉴定血清中的自身抗体，这些抗体可能作为潜在的癌症生物标志物。使用这些技术的初步研究结果是有希望的，并且表明糖组学将产生针对特定癌症的新型生物标志物，并且比现有的生物标志物具有更高的特异性。最近的研究结果表明，检测其他糖蛋白的糖型可能以更高的特异性和敏感性诊断肝炎向肝细胞癌的进展。由于这些和其他结果，日本和美国的政府资助机构已经开始了促进癌症糖组学生物标志物研究的项目。日美联合军演。“糖组学在临床癌症生物标志物发现中的应用”研讨会将汇集40位世界级的研究人员，他们专门研究糖组学技术并将其应用于疾病生物标志物的发现。糖组学研究正处于对疾病生物标志物最新进展的介绍和讨论对临床和转化应用的快速发展至关重要的阶段。迄今还没有举行过这类讲习班或会议。有机会举办这样一个创新的研讨会，通过提供一种分享新开发的技术和技术的手段，并允许参与者开展具体的合作，将极大地加速癌症生物标志物的发展。

DESCRIPTION (provided by applicant): The emerging field of Glycomics, the study of the structure and function of glycans, is poised to have a significant impact on the field of cancer biomarker discovery. Groups mainly concentrated in Japan and the United States have developed new technologies that allow a comprehensive analysis of glycans and glycopeptides from diseased human tissues and fluids as a means to identify potential cancer and other disease markers. Moreover, microarrays of printed glycans are available to identify auto-antibodies in serum that may serve as potential cancer biomarkers. Initial results from studies using these technologies are promising and suggest that Glycomics will yield novel biomarkers for specific cancers and provide increased specificity over those now available. Very recent results suggest detection of glycoforms of additional glycoproteins may provide diagnosis of progression of hepatitis to hepatocellular carcinoma with even higher specificity and sensitivity. Because of these and other results, governmental funding agencies in both Japan and the United States have begun programs to foster cancer glycomics biomarker research. The joint Japan-U.S. workshop, Glycomics applications for clinical cancer biomarker discovery, will bring together 40 world-class investigators who specialize in developing Glycomics technologies and applying them to the discovery of disease biomarkers. Glycomics research is just at the point where the presentation and discussion of recent advances applied to disease biomarkers are critical to the rapid development toward clinical and translational applications. No workshop or conference of this kind has yet been held. The opportunity to have an innovative workshop such as this will greatly accelerate the development of cancer biomarkers by providing a means to share newly developed techniques and technologies and allowing participants to develop specific collaborations. Public Health Relevance: This meeting will bring together researchers from around the world who apply findings in an area of research known as Glycomics to the development of cancer markers, particularly diagnostics. The meeting is expected to accelerate the development and testing of blood markers for several cancers. Having access to these types of diagnostic markers would facilitate an early, non- invasive diagnosis of cancers such as hepatocellular carcinoma and breast carcinoma, thereby allowing them to be treated at a early stage.