Translational and Clinical Research on Cancer: Glycomics Applications

描述（由申请人提供）：糖组学的新兴领域，即聚糖结构和功能的研究，有望对癌症生物标志物发现领域产生重大影响。主要集中在日本和美国的研究小组已经开发出新技术，可以对患病人体组织和体液中的聚糖和糖肽进行全面分析，作为识别潜在癌症和其他疾病标志物的一种手段。此外，打印聚糖的微阵列可用于鉴定血清中可用作潜在癌症生物标志物的自身抗体。使用这些技术的研究的初步结果是有希望的，并表明糖组学将为特定癌症产生新的生物标志物，并提供比现有技术更高的特异性。最近的结果表明，检测其他糖蛋白的糖型可以提供诊断肝炎进展为肝细胞癌，具有更高的特异性和敏感性。由于这些和其他结果，日本和美国的政府资助机构已经开始计划促进癌症糖组学生物标志物的研究。日美联合研讨会“Glycomics应用于临床癌症生物标志物发现”将汇集40名世界级研究人员，他们专门开发Glycomics技术并将其应用于发现疾病生物标志物。糖组学研究正处于介绍和讨论应用于疾病生物标志物的最新进展对临床和转化应用的快速发展至关重要的阶段。尚未举行过此类讲习班或会议。有机会举办这样的创新研讨会将大大加快癌症生物标志物的发展，提供一种分享新开发的技术和技术的手段，并允许参与者开展具体的合作。 公共卫生相关性：本次会议将汇集来自世界各地的研究人员，他们将糖组学研究领域的发现应用于癌症标志物的开发，特别是诊断。预计这次会议将加速几种癌症血液标志物的开发和测试。获得这些类型的诊断标志物将有助于癌症如肝细胞癌和乳腺癌的早期非侵入性诊断，从而允许在早期阶段对其进行治疗。

DESCRIPTION (provided by applicant): The emerging field of Glycomics, the study of the structure and function of glycans, is poised to have a significant impact on the field of cancer biomarker discovery. Groups mainly concentrated in Japan and the United States have developed new technologies that allow a comprehensive analysis of glycans and glycopeptides from diseased human tissues and fluids as a means to identify potential cancer and other disease markers. Moreover, microarrays of printed glycans are available to identify auto-antibodies in serum that may serve as potential cancer biomarkers. Initial results from studies using these technologies are promising and suggest that Glycomics will yield novel biomarkers for specific cancers and provide increased specificity over those now available. Very recent results suggest detection of glycoforms of additional glycoproteins may provide diagnosis of progression of hepatitis to hepatocellular carcinoma with even higher specificity and sensitivity. Because of these and other results, governmental funding agencies in both Japan and the United States have begun programs to foster cancer glycomics biomarker research. The joint Japan-U.S. workshop, Glycomics applications for clinical cancer biomarker discovery, will bring together 40 world-class investigators who specialize in developing Glycomics technologies and applying them to the discovery of disease biomarkers. Glycomics research is just at the point where the presentation and discussion of recent advances applied to disease biomarkers are critical to the rapid development toward clinical and translational applications. No workshop or conference of this kind has yet been held. The opportunity to have an innovative workshop such as this will greatly accelerate the development of cancer biomarkers by providing a means to share newly developed techniques and technologies and allowing participants to develop specific collaborations. Public Health Relevance: This meeting will bring together researchers from around the world who apply findings in an area of research known as Glycomics to the development of cancer markers, particularly diagnostics. The meeting is expected to accelerate the development and testing of blood markers for several cancers. Having access to these types of diagnostic markers would facilitate an early, non- invasive diagnosis of cancers such as hepatocellular carcinoma and breast carcinoma, thereby allowing them to be treated at a early stage.