IDENTIFICATION OF A PANCREATIC CARCINOMA-SPECIFIC N-LINKED GLYCAN EPITOPE

胰腺癌特异性 N 联聚糖表位的鉴定

• 批准号: 8363124
• 负责人: J. Michael Pierce
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363124
• 关键词: Adenocarcinoma; Binding; Cells; Epitopes; Funding; Goals; Grant; Link; Malignant neoplasm of pancreas; Monoclonal Antibodies; National Center for Research Resources; Pancreas; Pancreatic carcinoma; Pancreatitis; Peptide N-Glycosidase; Polysaccharides; Principal Investigator; Research; Research Infrastructure; Resources; Source; Technology; Tissues; United States National Institutes of Health; cost; pancreatic cancer cells

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this subproject is to identify the epitope recognized on pancreatic cancer cells that is recognized by the monoclonal antibody #109. This epitope shows specific binding for various adenocarcinomas, including pancreatic cells, and is unreactive to pancreatitis and control tissues. The epitope is sensitive to N-glycanase and is expressed on CEACAM6 uniquely in pancreatic cancer tissues.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该子项目的目标是鉴定胰腺癌细胞上可被单克隆抗体 #109 识别的表位。 该表位显示出与各种腺癌（包括胰腺细胞）的特异性结合，并且对胰腺炎和对照组织无反应。 该表位对 N-聚糖酶敏感，并且在胰腺癌组织中独特地在 CEACAM6 上表达。