MATERNAL HIGH FAT DIET PROGRAMS VASCULAR PATHOLOGY IN INFANTS

母亲高脂肪饮食计划 婴儿血管病理学

• 批准号: 8173252
• 负责人: KEVIN L GROVE
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173252
• 关键词: Animals; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Child; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diabetes Mellitus; Diet; Fatty acid glycerol esters; Fetus; Funding; Grant; Human; Hyperlipidemia; Infant; Institution; Intake; Metabolic; Metabolic Diseases; Modeling; Monkeys; Mothers; Neonatal; Obesity; Pathology; Play; Process; Reporting; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; early onset; fetal; high risk; hypercholesterolemia; nonhuman primate; offspring; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Evidence indicates that an abnormal maternal metabolic status, such as diabetes, exerts deleterious effects on the cardiovascular system of the fetus that may last for a lifetime. Arthrosclerosis is the process responsible for most cardiovascular disease. Recently it was reported that children born to obese mothers had a high risk of early development of fatty streaks in major vessels (an early sign of arthrosclerosis); however, it is unknown what maternal factors may be contributing to the early signs of cardiovascular disease in these children. Maternal obesity, diabetes, fat intake, hypercholesterolemia and hyperlipidemia are some factors that could play a critical pathophysiological role in the development of arthrosclerosis in children. We have developed a nonhuman primate model maternal diet induced obesity/diabetes, where monkeys are maintained on a high fat diet (HFD) for 2-4 years. These animals develop the full compliment of metabolic disease as humans and are thus an excellent model to begin to investigate the contributing factors to early onset cardiovascular disease. The purpose of this project is to begin to determine if there are signs of cardiovascular complications in fetal and neonatal offspring of HFD animals. Furthermore, these studies will provide the preliminary data to develop a hypothesis about what maternal factors may be contributing to the cardiovascular disease in the offspring.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 证据表明，诸如糖尿病之类的异常孕产妇代谢状况对可能持续一生的胎儿心血管系统施加有害影响。关节炎是导致大多数心血管疾病的过程。最近，据报道，肥胖母亲出生的儿童在主要血管中早期发育脂肪条纹的风险很高（关节炎的早期迹象）。但是，尚不清楚这些儿童中有哪些母体因素会导致心血管疾病的早期迹象。孕产妇肥胖，糖尿病，脂肪摄入，高胆固醇血症和高脂血症是某些因素，在儿童关节炎的发展中可能发挥关键的病理生理作用。我们已经开发了一种非人类灵长类动物模型孕妇饮食诱发的肥胖/糖尿病，在高脂饮食（HFD）上保持了2 - 4年。这些动物充分称赞代谢性疾病作为人类，因此是开始研究早期发作心血管疾病的促成因素的绝佳模型。该项目的目的是开始确定HFD动物的胎儿和新生儿后代中是否存在心血管并发症的迹象。此外，这些研究将提供初步数据，以建立一个假设，即关于哪些母体因素可能导致后代心血管疾病。