MATERNAL HIGH FAT DIET PROGRAMS VASCULAR PATHOLOGY IN INFANTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 有证据表明，母亲的代谢状态异常，如糖尿病，会对胎儿的心血管系统产生有害影响，可能会持续一生。关节硬化症是导致大多数心血管疾病的过程。最近有报道称，肥胖母亲所生的孩子早期出现主要血管脂肪条纹(关节硬化的早期征兆)的风险很高；然而，目前尚不清楚是什么母体因素导致了这些儿童心血管疾病的早期症状。母亲肥胖、糖尿病、脂肪摄入、高胆固醇血症和高脂血症在儿童关节硬化症的发生发展中起着关键的病理生理作用。我们开发了一种母性饮食诱导肥胖/糖尿病的非人灵长类动物模型，在该模型中，猴子被维持在高脂肪饮食(HFD)2-4年。这些动物与人类一样完全符合代谢性疾病，因此是开始研究早发性心血管疾病的促成因素的极佳模型。该项目的目的是开始确定HFD动物的胎儿和新生后代是否有心血管并发症的迹象。此外，这些研究将提供初步数据，以开发关于哪些母体因素可能导致后代心血管疾病的假说。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Evidence indicates that an abnormal maternal metabolic status, such as diabetes, exerts deleterious effects on the cardiovascular system of the fetus that may last for a lifetime. Arthrosclerosis is the process responsible for most cardiovascular disease. Recently it was reported that children born to obese mothers had a high risk of early development of fatty streaks in major vessels (an early sign of arthrosclerosis); however, it is unknown what maternal factors may be contributing to the early signs of cardiovascular disease in these children. Maternal obesity, diabetes, fat intake, hypercholesterolemia and hyperlipidemia are some factors that could play a critical pathophysiological role in the development of arthrosclerosis in children. We have developed a nonhuman primate model maternal diet induced obesity/diabetes, where monkeys are maintained on a high fat diet (HFD) for 2-4 years. These animals develop the full compliment of metabolic disease as humans and are thus an excellent model to begin to investigate the contributing factors to early onset cardiovascular disease. The purpose of this project is to begin to determine if there are signs of cardiovascular complications in fetal and neonatal offspring of HFD animals. Furthermore, these studies will provide the preliminary data to develop a hypothesis about what maternal factors may be contributing to the cardiovascular disease in the offspring.