MATERNAL HIGH FAT DIET PROGRAMS VASCULAR PATHOLOGY IN INFANTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 有证据表明，异常的母体代谢状态，如糖尿病，对胎儿的心血管系统产生有害影响，可能持续一生。关节硬化症是导致大多数心血管疾病的过程。最近有报道称，肥胖母亲所生的儿童在主要血管中早期出现脂肪条纹的风险很高（关节硬化症的早期体征）;然而，尚不清楚哪些母体因素可能导致这些儿童出现心血管疾病的早期体征。母亲肥胖、糖尿病、脂肪摄入、高胆固醇血症和高脂血症是可能在儿童关节硬化症的发展中发挥关键病理生理作用的一些因素。我们已经开发了非人灵长类动物模型母体饮食诱导的肥胖/糖尿病，其中猴子维持高脂肪饮食（HFD）2-4年。这些动物发展出与人类一样的代谢疾病，因此是开始研究早发性心血管疾病的促成因素的极好模型。本项目的目的是开始确定HFD动物的胎儿和新生儿后代是否存在心血管并发症的体征。此外，这些研究将提供初步数据，以建立一个关于哪些母体因素可能导致后代心血管疾病的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Evidence indicates that an abnormal maternal metabolic status, such as diabetes, exerts deleterious effects on the cardiovascular system of the fetus that may last for a lifetime. Arthrosclerosis is the process responsible for most cardiovascular disease. Recently it was reported that children born to obese mothers had a high risk of early development of fatty streaks in major vessels (an early sign of arthrosclerosis); however, it is unknown what maternal factors may be contributing to the early signs of cardiovascular disease in these children. Maternal obesity, diabetes, fat intake, hypercholesterolemia and hyperlipidemia are some factors that could play a critical pathophysiological role in the development of arthrosclerosis in children. We have developed a nonhuman primate model maternal diet induced obesity/diabetes, where monkeys are maintained on a high fat diet (HFD) for 2-4 years. These animals develop the full compliment of metabolic disease as humans and are thus an excellent model to begin to investigate the contributing factors to early onset cardiovascular disease. The purpose of this project is to begin to determine if there are signs of cardiovascular complications in fetal and neonatal offspring of HFD animals. Furthermore, these studies will provide the preliminary data to develop a hypothesis about what maternal factors may be contributing to the cardiovascular disease in the offspring.