Neuroscience Advanced Predoctoral Institutional Training Grant

描述（由申请人提供）：这个神经科学博士前培训计划的中心目标是继续为博士前学生提供个性化，高质量的培训，在他们的研究生学习的中后期，因为他们准备完成论文研究。我们在各个层面提供广泛的多学科培训，在核心概念，技能，方法和科学文献的高级理解方面奠定了坚实的基础。我们新修订的核心课程指导学生在基因，细胞，系统，认知，转化神经科学和神经系统疾病的水平。我们培养一个不受传统学科界限约束的环境，鼓励研究生在这些学科的接口工作。在教学的各个阶段，我们整合了被认为是神经科学成功，独立研究职业所必需的技能。这些包括批判性思维和推理，有效的科学写作和口头陈述，科学审查过程的知识，以及道德培训。对于这个程序，我们将扩大最近的举措，以确保研究生有接触神经科学的临床和疾病的概念。这些措施包括从布朗临床医生纳入我们的核心课程研讨会，出席在布朗附属医院神经病学，神经病理学和精神病学的大回合;和一个新的研究生，只有疾病的神经生物学课程的第3年强制出席。我们的大多数博士前学员继续在学术界或生物技术行业的神经系统的基础科学调查。我们希望在他们的培训早期接触临床问题将积极影响他们的研究生涯。在布朗神经科学研究生课程的主要特点包括：在研究沿着卓越的教育和指导;跨学科和翻译研究的历史，特别是在计算神经科学;和小，但生产力高的实验室，研究生在研究过程中平等的合作伙伴的环境。拟议的培训计划有29名参与教师，来自六个不同的布朗大学部门和约50名博士前学员的目标。教师培训师是一群杰出而充满活力的脑科学家，他们共同涵盖了从基因到认知的现代神经科学研究的范围。我们有适当的结构，鼓励和促进计算和转化神经科学的研究，这些研究位于工程，应用数学和神经科学等学科的界面。我们的培训涵盖了我们认为对神经科学事业成功至关重要的最先进方法的全方位。这些研究包括非侵入性功能性磁共振成像、机器人技术和神经修复术的应用、先进的电生理记录、小鼠转基因、行为研究、神经元基因的分子操作和功能蛋白质组学

DESCRIPTION (provided by applicant): The central objective of this pre-doctoral training program in Neuroscience is to continue providing individualized, high quality training to pre-doctoral students in their middle-to-late years of graduate studies as they prepare to finish their dissertation research. We provide broad, multi-disciplinary training at all levels with a strong foundation in core concepts, skills, methodologies, and advanced comprehension of the scientific literature. Our newly revised core curriculum instructs students at the level of genes, cells, systems, cognition, translational neuroscience, and diseases of the nervous system. We foster an environment unconstrained by traditional discipline boundaries and where graduate students are encouraged to work at the interfaces of these disciplines. At all stages of instruction, we integrate skills considered essential for successful, independent research careers in neuroscience. These include critical thinking and reasoning, effective science writing and oral presentation, knowledge of scientific review processes, and training in ethics. For this program, we will expand recent initiatives to ensure that graduate students have exposure to clinical and disease concepts in neuroscience. These include incorporating seminars from clinicians at Brown into our core curriculum, attendance at Grand Rounds in Neurology, Neuropathology, and Psychiatry at Brown-affiliated Hospital; and compulsory attendance in Year 3 of a new graduate-student only Neurobiology of Disease Course. The majority of our pre-doctoral trainees continue in basic scientific investigations of the nervous system either in academia or in the biotechnology industry. We expect that exposure to clinical issues early in their training will positively influence their research careers. Key features of the Neuroscience Graduate Program at Brown include: Excellence in research along with excellence in education and mentorship; a history of interdisciplinary and translational research particularly in computational neuroscience; and an environment of small but highly productive laboratories where graduate students are equal partners in the research process. The proposed training program has 29 participating faculty, drawn from six different Brown University departments and a target of about 50 pre-doctoral trainees. The faculty trainers are a distinguished and energetic group of brain scientists that collectively cover the spectrum of modern neuroscience research from genes to cognition. We have structures in place that encourage and facilitate research in computational and translational neuroscience that reside at the interface of disciplines including engineering, applied mathematics and neuroscience. Our training covers the full-spectrum of state-of-the art methodologies that we consider essential for a successful career in the neurosciences. These include non-invasive functional MRI, applications of robotics and neuroprosthetics, advanced electrophysiological recordings, mouse transgenics, behavioral studies, molecular manipulations of neuronal genes and functional proteomics