权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Cognitive and Brain Processes in Individuals with Childhood Interpersonal Trauma

童年人际创伤个体的认知和大脑过程

基本信息

批准号：
8013589
负责人：
Marie T Banich
金额：
$ 7.07万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-01-15 至 2012-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8013589
关键词：
Address Adolescence Adult Affect Age Amygdaloid structure Anatomy Anxiety Attention Basic Science Behavioral Brain Brain region Brain scan Child Abuse Childhood Clinical Cognitive Cognitive deficits Collaborations Coombs&apos Test Corpus Callosum Country Data Development Diagnosis Diffusion Magnetic Resonance Imaging Disease Distress Early treatment Emotional Functional Magnetic Resonance Imaging Goals Hour Individual Intervention Investigation Journals Knowledge Laboratories Link Memory Mental Depression National Institute of Child Health and Human Development Nature Neurophysiology - biologic function Outcome Participant Pattern Pear Post-Traumatic Stress Disorders Prefrontal Cortex Process Psychologist Psychopathology Publishing Recording of previous events Regulation Relative (related person)Reporting Research Resolution Scanning Science Sensitivity Training Groups Severities Sexual abuse Short-Term Memory Support System Symptoms System Therapeutic Intervention Thinking Time Trauma United States Dept. of Health and Human Services United States National Academy of Sciences Work base cognitive control cognitive function design emerging adult experience falls graduate student medical specialties meetings neurodevelopment neuromechanism neuroregulation pediatric trauma physical abuse relating to nervous system young adult

项目摘要

DESCRIPTION (provided by applicant): The goal of the present project is to understand the effects in early adulthood of interpersonal trauma experienced during childhood. In particular, the project will examine the hypothesis that long-lasting changes are observed in cognitive processes and the brain systems that support such processes as a result of childhood interpersonal trauma (CIT). The project has two specific aims. The first specific aim is to examine the hypothesis that neural systems involved in attentional control and in the selection of information in working memory will be compromised in individuals with a history of CIT (T+) as compared to those without (T-). In particular, the prediction is that individuals with a history of childhood interpersonal trauma will have a poorer ability to ignore distracting information, both of an emotional and non-emotional nature, and that this will be accompanied with reduced activity in regions of dorsolateral prefrontal cortex that are associated with top- down attentional control. An additional prediction is that individuals with a history of childhood interpersonal trauma will have a reduced ability to control the contents of working memory, especially when such information must be inhibited or "cleared" out. These effects will be accompanied by reduced activity in regions of dorsolateral prefrontal cortex associated with control over the contents of working memory. The second aim is to investigate the hypothesis that the compromise of functioning of these neural control mechanisms will increase with severity of symptomatology related to trauma. In particular, an increase in the degree of intrusive thoughts is predicted to be associated with more compromise of these cognitive functions and neural systems. There is one exploratory aim, which is to examine the hypothesis that individuals with a history of childhood interpersonal trauma as compared to those without will show alterations in brain anatomy, most notably in prefrontal regions and the corpus callosum. These hypotheses will be investigated in one study in which individuals will participate in two 1.25 hour sessions. The first session is designed to obtain information about the trauma history of the individual while also obtaining related information such as their degree of anxiety, worry, depression and intrusive thoughts. The second session involves functional and anatomical brain scanning. In this session individuals will perform two tasks, an attention task and a working memory task while their brain activity is assessed using functional magnetic resonance imaging (fMRI). In addition, a high- resolution anatomical scan and a diffusion tensor imaging scan will be obtained so that brain anatomy can be compared between the two groups and also related to symptomatology within the childhood interpersonal trauma (T+) group. The proposed research will provide information on how specific experiences (i.e., trauma) during the childhood period impact both cognitive and neural development. Such knowledge is critical for designing early intervention and treatments aimed at countering and ameliorating the effects of trauma.

描述（由申请人提供）：本项目的目标是了解童年经历的人际创伤对成年早期的影响。特别是，该项目将检验一个假设，即儿童人际创伤（CIT）导致认知过程和支持这些过程的大脑系统发生了持久的变化。该项目有两个具体目标。第一个具体目标是检验一个假设，即有CIT （T+）病史的个体与没有（T-）病史的个体相比，在工作记忆中涉及注意力控制和信息选择的神经系统会受到损害。特别是，该研究预测，有童年人际关系创伤史的个体忽视分散注意力信息的能力较差，无论是情绪上的还是非情绪上的，而且这将伴随着与自上而下的注意力控制相关的背外侧前额叶皮层区域的活动减少。另一个预测是，有童年人际创伤史的人控制工作记忆内容的能力会降低，尤其是当这些信息必须被抑制或“清除”时。这些影响将伴随着与控制工作记忆内容相关的背外侧前额叶皮层区域活动的减少。第二个目的是研究这些神经控制机制功能的损害将随着创伤相关症状的严重程度而增加的假设。特别是，据预测，侵入性思想程度的增加与这些认知功能和神经系统的更多损害有关。有一个探索性的目的，即检验一个假设，即与那些没有童年人际创伤史的人相比，有童年人际创伤史的人会在大脑解剖结构上表现出改变，最明显的是在前额叶区域和胼胝体。这些假设将在一项研究中进行调查，在这项研究中，个人将参加两个1.25小时的会议。第一阶段的目的是获得有关个人创伤史的信息，同时也获得相关信息，如他们的焦虑、担忧、抑郁和侵入性想法的程度。第二阶段包括功能性和解剖性脑扫描。在这一阶段，受试者将执行两项任务，一项是注意力任务，另一项是工作记忆任务，同时使用功能性磁共振成像（fMRI）评估他们的大脑活动。此外，将获得高分辨率解剖扫描和弥散张量成像扫描，以便比较两组之间的脑解剖结构，并与儿童人际创伤（T+）组的症状学相关。拟议的研究将提供关于儿童时期的具体经历（即创伤）如何影响认知和神经发育的信息。这些知识对于设计旨在对抗和改善创伤影响的早期干预和治疗至关重要。