14/21 ABCD-USA Consortium: Research Project Site at CU Boulder

摘要 神经影像学扩展了我们对从童年到成年早期大脑发育的理解。 随着时间的推移，青少年药物使用趋势发生了变化，但大麻，酒精和烟草的使用仍然存在 这种情况普遍存在，通常始于青少年时期，严重的心理健康状况也往往出现。 虽然身体健康正处于一生的高峰期，但青少年的新问题包括： 抑郁、焦虑、社交孤立、自杀意念和过度使用屏幕媒体。的程度 早期物质使用和其他环境暴露可能使青少年处于改变神经发育的风险中 对不良后果的了解仍然很少。 从ABCD研究联盟的21个地点招募了11，878名9-10奥尔兹的多样化样本 根据RFA-DA-15-015。所有参与者都接受了全面的基线评估，包括 最先进的脑成像，全面的神经心理学测试，生物测定，仔细评估物质 使用、心理健康、身体健康、文化和环境，以及每两年进行一次移动的监测。临时- 个人年度访谈和一年两次的电话或移动的应用程序评估， 解决行为，发展和生活事件，最小的参与者负担。密集的努力是 使绝大多数参与者通过青春期及以后的学习， 非常高。 与科学界安全和私下共享的数据将使研究人员能够：（1）描述 在神经、认知、情感和学业功能方面的个人发展轨迹，以及 影响因素;（2）制定健康脑发育的国家标准;（3）研究健康脑发育的作用， 基因和环境对发育的相互作用;（4）研究体力活动，睡眠，屏幕 时间，运动损伤（包括创伤性脑损伤）和其他经历会影响大脑发育;（5） 确定和复制影响精神疾病发作、病程和严重程度的因素;（6） 描述精神健康和物质使用之间的关系;（7）具体说明如何使用不同的 物质（例如，大麻，酒精，烟草，咖啡因）影响发育结果，以及神经， 认知、情绪和环境因素影响物质使用风险。

Abstract Neuroimaging has expanded our understanding of brain development from childhood into early adulthood. Adolescent substance use trends have shifted over time, but use of cannabis, alcohol, and tobacco remain prevalent, typically starting during teenage years, when serious mental health conditions also tend to emerge. Although physical health is at its lifetime peak, emerging concerns for teens include increasing rates of depression, anxiety, social isolation, suicidal ideation, and excessive use of screen media. The extent to which early substance use and other environmental exposures may place youth at risk for altered neurodevelopment and adverse outcomes remains poorly understood. A diverse sample of 11,878 9-10 year olds was enrolled from 21 sites across the ABCD Study consortium under RFA-DA-15-015. All participants underwent a comprehensive baseline assessment, including state-of- the-art brain imaging, comprehensive neuropsychological testing, bioassays, careful assessment of substance use, mental health, physical health, culture and environment, and mobile monitoring every 2 years. Interim in- person annual interviews and biannual telephone or mobile app assessments provide refined temporal resolution of behaviors, development, and life events with minimal participant burden. Intensive efforts are made to retain the vast majority of participants through adolescence and beyond and retention rates thus far are very high. Data, securely and privately shared with the scientific community, will enable investigators to: (1) describe individual developmental trajectories in terms of neural, cognitive, emotional, and academic functioning, and influencing factors; (2) develop national standards of healthy brain development; (3) investigate the roles and interaction of genes and the environment on development; (4) examine how physical activity, sleep, screen time, sports injuries (including traumatic brain injuries), and other experiences affect brain development; (5) determine and replicate factors that influence the onset, course, and severity of mental illnesses; (6) characterize the relationship between mental health and substance use; and (7) specify how use of different substances (e.g., cannabis, alcohol, tobacco, caffeine) affects developmental outcomes, and how neural, cognitive, emotional, and environmental factors influence substance use risk.