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14/21 ABCD-USA Consortium: Research Project Site at CU Boulder

14/21 ABCD-美国联盟：科罗拉多大学博尔德分校研究项目现场

基本信息

批准号：
10598049
负责人：
Marie T Banich
金额：
$ 162.67万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598049
关键词：
10 year old Address Adolescence Adolescent Affect Age Alcohol consumption Alcohols Anxiety Athletic Injuries Behavior Bioinformatics Biological Assay Brain Brain imaging Caffeine Calendar Cannabis Child Childhood Clinical assessments Cognition Cognitive Communities Data Data Analyses Decision Making Development Emotional Enrollment Ensure Environment Environmental Exposure Environmental Risk Factor Epidemiology Ethics Event Feeling suicidal Female Funding Genetic Impairment Individual Informatics Interview Life Link Mental Depression Mental Health Mental disorders Methodology Methods Monitor Neurocognition Neurocognitive Neuropsychological Tests Occupations Outcome Parents Participant Persons Physical activity Privatization Process Protocols documentation Psychopathology Qualifying Registries Research Research Personnel Research Project Grants Resources Risk Role Sampling Schools Science Secure Severities Siblings Site Sleep Social Functioning Social isolation Specific qualifier value Standardization Symptoms Teenagers Telephone Text Time Tobacco Tobacco use Training Traumatic Brain Injury Triplet Multiple Birth Twin Multiple Birth Youth adolescent substance use adverse outcome assessment application cognitive development cognitive testing cohort college design emerging adult emotional factor experience follow-up gene interaction informatics infrastructure marijuana use mobile application mobile computing multimodality neural neurodevelopment neuroimaging novel participant enrollment participant retention physical conditioning recruit research and development response retention rate substance use temporal measurement trend tv watching

项目摘要

Abstract Neuroimaging has expanded our understanding of brain development from childhood into early adulthood. Adolescent substance use trends have shifted over time, but use of cannabis, alcohol, and tobacco remain prevalent, typically starting during teenage years, when serious mental health conditions also tend to emerge. Although physical health is at its lifetime peak, emerging concerns for teens include increasing rates of depression, anxiety, social isolation, suicidal ideation, and excessive use of screen media. The extent to which early substance use and other environmental exposures may place youth at risk for altered neurodevelopment and adverse outcomes remains poorly understood. A diverse sample of 11,878 9-10 year olds was enrolled from 21 sites across the ABCD Study consortium under RFA-DA-15-015. All participants underwent a comprehensive baseline assessment, including state-of- the-art brain imaging, comprehensive neuropsychological testing, bioassays, careful assessment of substance use, mental health, physical health, culture and environment, and mobile monitoring every 2 years. Interim in- person annual interviews and biannual telephone or mobile app assessments provide refined temporal resolution of behaviors, development, and life events with minimal participant burden. Intensive efforts are made to retain the vast majority of participants through adolescence and beyond and retention rates thus far are very high. Data, securely and privately shared with the scientific community, will enable investigators to: (1) describe individual developmental trajectories in terms of neural, cognitive, emotional, and academic functioning, and influencing factors; (2) develop national standards of healthy brain development; (3) investigate the roles and interaction of genes and the environment on development; (4) examine how physical activity, sleep, screen time, sports injuries (including traumatic brain injuries), and other experiences affect brain development; (5) determine and replicate factors that influence the onset, course, and severity of mental illnesses; (6) characterize the relationship between mental health and substance use; and (7) specify how use of different substances (e.g., cannabis, alcohol, tobacco, caffeine) affects developmental outcomes, and how neural, cognitive, emotional, and environmental factors influence substance use risk.

摘要