REGULATION OF GENE EXPRESSION IN HUMAN BLADDER TISSUE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在与Videra博士合作，将人类膀胱癌组织唾液酸化和唾液酸化转移酶转录水平的变化联系起来。这些研究刚刚开始，但先前的数据表明膀胱癌样本中唾液酸化的糖链结构上调，我们的合作研究集中在确定这些结构是由唾液酸基转移酶还是唾液酸酶在这些转化组织中转录调节而产生的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are collaborating with Dr. Videra to correlate changes in tissue sialylation and sialyltransferase transcript levels in human bladder cancer. These studies have just been initiated, but prior data indicated an upregulation of sialylated glycan structures in the bladder cancer samples and our collaborative studies are focused on determining if these structures are generated by transcriptional regulation of sialyltransferases or sialidases in these transformed tissues.