BIOMARKER DISCOVERY FOR PATHOLOGICAL PLACENTAL MALARIA

病理性胎盘疟疾生物标志物的发现

• 批准号: 8363040
• 负责人: KELLEY W. MOREMEN
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363040
• 关键词: Biological Markers; Collaborations; Evaluation; Funding; Gene Expression; Genes; Glycosaminoglycans; Goals; Grant; Infection; Inorganic Sulfates; Literature; Malaria; National Center for Research Resources; Polysaccharides; Principal Investigator; Reporting; Research; Research Infrastructure; Resources; Role; Source; Stimulus; Syncytiotrophoblast; Technology; Transcript; United States National Institutes of Health; Unspecified or Sulfate Ion Sulfates; cost; programs; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of Dr. Moore's research program is to identify biomarkers for pathological placental malaria. The experimental approach for our collaboration will be to elucidate changes in glycan-related gene expression in syncytiotrophoblast following treatment with various stimuli using our qRT-PCR platform. Previous reports in the literature on placental malaria have implicated a role for glycosaminoglycans (GAGs)(ie. Chondriotin Sulfate A) in malarial infection. Our initial experiments will include evaluation of transcript abundance of GAG-related genes.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 摩尔博士研究项目的目标是确定病理性胎盘疟疾的生物标记物。我们合作的实验方法将是利用我们的qRT-PCR平台来阐明不同刺激处理后合体滋养层细胞中糖相关基因表达的变化。以前关于胎盘疟疾的文献报道都暗示了糖胺聚糖(GAG)的作用(即。硫酸软骨素A)在疟疾感染中的作用。我们的初步实验将包括评估GAG相关基因的转录丰度。