REGULATION OF GENE EXPRESSION IN HUMAN BLADDER TISSUE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们正在与Videra博士合作，将人类膀胱癌组织唾液酸化和唾液酸化转移酶转录水平的变化联系起来。这些研究刚刚开始，但先前的数据表明膀胱癌样本中唾液酸化的糖链结构上调，我们的合作研究集中在确定这些结构是由唾液酸基转移酶还是唾液酸酶在这些转化组织中转录调节而产生的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are collaborating with Dr. Videra to correlate changes in tissue sialylation and sialyltransferase transcript levels in human bladder cancer. These studies have just been initiated, but prior data indicated an upregulation of sialylated glycan structures in the bladder cancer samples and our collaborative studies are focused on determining if these structures are generated by transcriptional regulation of sialyltransferases or sialidases in these transformed tissues.