REGULATION OF MUCIN-RELATED GENE EXPRESSION

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们正在分析编码肠粘蛋白生物合成酶和核心蛋白的转录本，在肠道细菌（空肠弯曲杆菌）感染的小鼠模型中。 Michael McGuckin博士（Mater医学研究所，南布里斯班，澳大利亚）正在制备受感染小鼠肠道的样本，Karlsson博士正在分析粘蛋白结构，而我们的小组正在分析转录水平。 这些研究的目的是检查肠道细菌感染后粘蛋白表达的反应。 这些研究刚刚开始，我们预计将持续进行合作，可能需要一段时间才能以提交手稿的形式取得成果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are analyzing transcripts encoding intestinal mucin biosynthetic enzymes and core proteins in a mouse model for intestinal bacterial (Campylobacter jejuni) infection. Samples of infected mouse intestine are being generated by Dr. Michael McGuckin (Mater Medical Research Institute, South Brisbane, Australia) and Dr. Karlsson is analyzing mucin structures, while our group is analyzing transcript levels. The goals of these studies are to examine the responses in mucin expression following a challenge of bacterial infection in the intestinal tract. These studies have just started and we anticipate an ongoing collaboration that may take a period of time to reach fruition in the form of submitted manuscripts.