NON-HUMAN PRIMATE PROPAGATION BY SOMATIC CELL NUCLEAR TRANSFER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的主要目标是了解核移植的基本生物学，最终目标是进一步了解胚胎干细胞，并可能产生克隆的非人类灵长类动物后代。 为了实现这一目标，将从狒狒中收集卵母细胞，然后在实验室中以各种方式进行操作，以产生克隆和/或对照胚胎。 这些胚胎中的大多数将保留在实验室中用于体外研究。 然而，一部分胚胎将被转移到受体雌性体内，以建立妊娠。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There major goal of this project is to understand the underlying biology of nuclear transfer, with the ultimate goal of furthering the understanding of embryonic stem cells and to perhaps produce a cloned non-human primate offspring. In order to achieve this, oocytes will be collected from baboons and then manipulated in various ways in the lab to produce cloned and/or control embryos. The majority of these embryos will be retained in the laboratory for use in in vitro studies. However, a portion of the embryos will be transferred into recipient females in order to establish pregnancies.