Frontiers in Aging and Regeneration Research (FrARR)

描述(由申请者提供)：这个R25研究教育应用程序题为：‘Frontiers in Aging and Regenerative Medicine(FrARR)’，响应PAR-12-016，培训和指导来自主要代表不足的社区的有前途的低年级和高级本科生进行复杂的老龄化研究，并鼓励和支持他们开始研究生学习。FARR提供：首先是动态培训课程，然后通过高级导师的指导和同行指导加强导师-学员伙伴关系，通过年度研讨会和科学务虚会丰富伙伴关系，并对职业轨迹进行量化跟踪。这些课程在HBCU机构提供，即泽维尔大学(1年级和4年级)、莫尔豪斯(2年级和5年级)和梅哈里(3年级)，由Gerald Schatten(匹兹堡)和S.Michael Jazwinski(杜兰)担任总董事，Shubha Kale爱尔兰(泽维尔)，Winston Thompson(莫尔豪斯)和Ayman Al-Hendy(Meharry)。我们的科学顾问咨询委员会由老龄化、再生和健康差距领域的知名专家组成，负责监督这一倡议。这五个具体目标是：1.激发教师对科学事业的热情、热情和承诺，为本科生完成硕士学位提供智力和情感上的支持。这是通过概念教育和实验室培训实现的，重点是与老龄化和非裔美国人社区有关的疾病和障碍。教学培训包括：A.衰老生物学和干细胞模型；B.衰老和阿尔茨海默病的神经生物学；C.肌肉和骨骼衰老；D.生殖衰老；以及E.表观遗传学和环境衰老调节剂，以及补充实验室。促进坦率地对待目前在招募和留住我们最有才华的研究人员方面的障碍，以及在负责任地进行研究、伦理、法律和社会影响方面的培训，特别是研究中的少数群体健康差距问题。通过有指导的研究项目和持续的职业建议，激励、支持和支持学员过渡到专业职业生涯。通过在伍兹霍尔的年度团聚研讨会上的演讲，提高他们日益增长的兴趣，同时也是MBL的老龄化课程。课程校友提供同龄人的指导。通过指导学员和校友完成研究生申请和入学程序，鼓励和增强他们的能力，使他们能够迅速和顺利地开始老龄研究和再生医学方面的博士学习。用量化的独立机制评估、改进和监测FrARR的长处和弱项，全面和纵向跟踪学员的成就，确保这些宝贵的资金能够量化地展示为明智、高性价比和富有成效的投资。总而言之，我们的总体目标是为未被充分代表的学员提供全面而复杂的研究策略和职业发展培训，以推动在老龄化和再生医学领域开拓前沿的科学工作队伍。

DESCRIPTION (provided by applicant): This R25 research education application entitled: 'Frontiers in Aging and Regenerative Medicine (FrARR),' responsive to PAR-12-016, trains and mentors promising junior and senior undergraduates from predominately underrepresented communities in sophisticated aging research, and encourages and supports them as they embark on graduate studies. FrARR offers: first, dynamic training courses, then nurtured Mentor-Trainee partnerships enhanced by guidance from Senior Mentors and peer-peer mentoring, enriched by annual symposia and scientific retreats, with quantitative tracking of career trajectories. The courses are offered at HBCU institutions, i.e. Xavier University (years 1 & 4), Morehouse (years 2 & 5) and Meharry (year 3), under the overall directorship of Gerald Schatten (Pittsburgh) and S. Michael Jazwinski (Tulane), with Shubha Kale Ireland (Xavier), Winston Thompson (Morehouse), and Ayman Al-Hendy (Meharry). Our Advisory Board of Scientific Counselors, composed of acclaimed experts in the fields of aging, regeneration and health disparities, oversee this initiative. The five specific aims are: I. Engendering the enthusiasm, passions and commitments to scientific careers embraced by the faculty provides intellectual and emotional underpinnings for supporting undergraduate trainees as they complete their MSTEM degrees. This is accomplished via conceptual education and laboratory training, focused on diseases and disorders relevant to aging and African- American communities. Didactic training includes: A. Biology of Aging and Stem Cell Models; B. Neurobiology of Aging and Alzheimer's disease; C. Muscle and Bone Aging; D. Reproductive Aging; and E. Epigenetics and Environmental Modulators of Aging, along with complementary labs. II. Fostering candid regarding current barriers to the recruitment and retention of our most talented researchers and training in responsible conduct of research, ethical, legal and societal implications, and especially problems of minority health disparities in research. III. Motivate, Enable and Sustain Trainees as they transition to professional careers, with mentored research projects and on-going career advice. Enhance their growing interests by their presentations at the Annual Reunion Symposia at Woods Hole contemporaneously with the MBL's Aging Course. Course alumni provide peer-peer mentorship. IV. Encouraging and empowering trainees and alumni by guiding them through the graduate application and matriculation processes so that they are rapidly and smoothly able to initiate doctoral studies in aging research and regenerative medicine. V. Evaluate, Improve and Monitor FrARR's strengths and avoid weaknesses with quantitative independent mechanisms, track trainees' achievements comprehensively and longitudinally, to ensure that these precious funds can be quantitatively demonstrated as wise, cost-effective and fruitful investments. In summary, our overall goals are to provide comprehensive sophisticated training in research strategies and career launching for underrepresented trainees to advance the scientific workforce pioneering the Frontiers in Aging and Regenerative Medicine.