Frontiers in Aging and Regeneration Research (FrARR)

描述（由申请人提供）：这个R25研究教育申请题为：“老龄化和再生医学前沿（FrARR）”，响应PAR-12-016，培训和指导来自主要代表性不足的社区的有前途的大三和大四本科生进行复杂的老龄化研究，并鼓励和支持他们开始研究生学习。FrARR提供：首先，动态培训课程，然后培育导师与学员的伙伴关系，由资深导师的指导和同行指导加强，通过年度专题讨论会和科学务虚会充实，并对职业轨迹进行定量跟踪。这些课程在HBCU机构提供，即泽维尔大学（1年级和4年级），莫尔豪斯（2年级和5年级）和梅哈里（3年级），由Gerald Schatten（匹兹堡）和S. Michael Jazwinski（杜兰），Shubha Kale Ireland（泽维尔），Winston Thompson（莫尔豪斯）和Ayman Al-Hendy（梅哈里）担任总董事。我们的科学顾问顾问委员会，由衰老、再生和健康差异领域的知名专家组成，监督这一倡议。这五个具体目标是：1 .培养教师对科学事业的热情、激情和承诺，为支持本科学员完成MSTEM学位提供智力和情感基础。这是通过概念教育和实验室培训来完成的，重点是与老龄化和非裔美国人社区有关的疾病和失调。教学培训包括：A.衰老生物学和干细胞模型；B.衰老与阿尔茨海默病的神经生物学；C.肌肉和骨骼老化；D.生殖老化；E.表观遗传学和衰老的环境调节剂，以及补充实验室。2。促进对目前招聘和留住我们最有才华的研究人员的障碍以及在负责任的研究行为、伦理、法律和社会影响方面的培训，特别是在研究中少数群体健康差异的问题上的坦诚。3。通过指导研究项目和持续的职业建议，激励、支持和支持学员向专业职业过渡。通过他们在伍兹霍尔举行的年度聚会研讨会上的演讲，以及MBL的老龄化课程，增强他们日益增长的兴趣。课程校友提供同侪指导。四、鼓励和授权学员和校友，指导他们完成研究生申请和入学流程，使他们能够迅速、顺利地开始衰老研究和再生医学的博士研究。五、通过独立的量化机制，评估、改进和监测FrARR的优势和不足，全面、纵向地跟踪学员的成果，确保这些宝贵的资金能够定量地证明是明智的、具有成本效益的和富有成效的投资。总之，我们的总体目标是为未被充分代表的受训者提供全面的研究策略和职业发展培训，以推动科学劳动力开拓衰老和再生医学的前沿。

DESCRIPTION (provided by applicant): This R25 research education application entitled: 'Frontiers in Aging and Regenerative Medicine (FrARR),' responsive to PAR-12-016, trains and mentors promising junior and senior undergraduates from predominately underrepresented communities in sophisticated aging research, and encourages and supports them as they embark on graduate studies. FrARR offers: first, dynamic training courses, then nurtured Mentor-Trainee partnerships enhanced by guidance from Senior Mentors and peer-peer mentoring, enriched by annual symposia and scientific retreats, with quantitative tracking of career trajectories. The courses are offered at HBCU institutions, i.e. Xavier University (years 1 & 4), Morehouse (years 2 & 5) and Meharry (year 3), under the overall directorship of Gerald Schatten (Pittsburgh) and S. Michael Jazwinski (Tulane), with Shubha Kale Ireland (Xavier), Winston Thompson (Morehouse), and Ayman Al-Hendy (Meharry). Our Advisory Board of Scientific Counselors, composed of acclaimed experts in the fields of aging, regeneration and health disparities, oversee this initiative. The five specific aims are: I. Engendering the enthusiasm, passions and commitments to scientific careers embraced by the faculty provides intellectual and emotional underpinnings for supporting undergraduate trainees as they complete their MSTEM degrees. This is accomplished via conceptual education and laboratory training, focused on diseases and disorders relevant to aging and African- American communities. Didactic training includes: A. Biology of Aging and Stem Cell Models; B. Neurobiology of Aging and Alzheimer's disease; C. Muscle and Bone Aging; D. Reproductive Aging; and E. Epigenetics and Environmental Modulators of Aging, along with complementary labs. II. Fostering candid regarding current barriers to the recruitment and retention of our most talented researchers and training in responsible conduct of research, ethical, legal and societal implications, and especially problems of minority health disparities in research. III. Motivate, Enable and Sustain Trainees as they transition to professional careers, with mentored research projects and on-going career advice. Enhance their growing interests by their presentations at the Annual Reunion Symposia at Woods Hole contemporaneously with the MBL's Aging Course. Course alumni provide peer-peer mentorship. IV. Encouraging and empowering trainees and alumni by guiding them through the graduate application and matriculation processes so that they are rapidly and smoothly able to initiate doctoral studies in aging research and regenerative medicine. V. Evaluate, Improve and Monitor FrARR's strengths and avoid weaknesses with quantitative independent mechanisms, track trainees' achievements comprehensively and longitudinally, to ensure that these precious funds can be quantitatively demonstrated as wise, cost-effective and fruitful investments. In summary, our overall goals are to provide comprehensive sophisticated training in research strategies and career launching for underrepresented trainees to advance the scientific workforce pioneering the Frontiers in Aging and Regenerative Medicine. PUBLIC HEALTH RELEVANCE: The research workforce does not represent the full rich diversity of America and this R25 research education application entitled: 'Frontiers in Aging and Regenerative Medicine (FrARR),' responsive to PAR-12-016, seeks to rectify this unacceptable situation. It trains and mentors promising junior and senior undergraduates from predominately underrepresented communities in sophisticated aging research and encourages and supports them as they embark on graduate studies. FrARR offers: first, dynamic training courses, then nurtured Mentor- Trainee partnerships enhanced by guidance from Senior Mentors and peer-peer mentoring, enriched by annual symposia and scientific retreats, with quantitative tracking of career trajectories. The courses are offered at HBCU institutions, i.e. Xavier University (years 1 & 4), Morehouse (years 2 & 5) and Meharry (year 3), under the overall directorship of Gerald Schatten (Pittsburgh) and S. Michael Jazwinski (Tulane), with Shubha Kale Ireland (Xavier), Winston Thompson (Morehouse), and Ayman Al-Hendy (Meharry). Our Advisory Board of Scientific Counselors, composed of acclaimed experts in the fields of aging, regeneration and health disparities, oversee this initiative. In summary, our overall goals are to provide comprehensive sophisticated training in research strategies and career launching for underrepresented trainees to advance the scientific workforce pioneering the Frontiers in Aging and Regenerative Medicine.