Research Training in Hematology

描述（由申请人提供）：目前的培训计划汇集了来自校园内共九个部门的二十名教师，专注于血液学和人类疾病的两个广泛重要领域：血管生物学和干细胞生物学/血液恶性肿瘤。这项补助金的主要目标是培养一个混合的医学博士。和博士具有杰出潜力的科学家在这些领域开展持续的独立研究计划。两个博士前职位要求利用优秀的医学博士池-博士候选人和强大的研究生课程在威斯康星州大学的悠久传统。临床研究者跟踪的研究员或住院医师来自参与的临床科室（内科、儿科、病理学和外科）和博士。将从参与的基础科学部门（解剖学，生物化学，生物统计学，微生物学和药理学）中挑选学员担任四个博士后职位。教师是一个稳定和互动的群体，聚集在三个主要的利益集团：止血/炎症，血液恶性肿瘤和人类干细胞/骨髓移植的基础和临床方面。该学院在基础科学和临床科学方面拥有广泛的专业知识，包括基因阵列和基因组学，转录和转录后基因表达，蛋白质结构分析，蛋白质组学，细胞生物学，造血和内皮细胞培养，小鼠动物模型，灵长类动物和人类胚胎干细胞以及骨髓移植的实验方法。有一个强有力的重点oh提供所需的多学科培训，以追求转化研究的机会，和临床研究人员的正式培训。我们的培训计划利用了威斯康星州大学的临床研究者预备计划（K30补助金），为从事转化研究项目的候选人提供临床试验设计和生物统计学方面的教学培训。该计划在保留学术医学实习生方面有着出色的记录。在我们的八名博士候选人中，有六名继续攻读博士学位。其中两人已完成学位，并在外部机构（哈佛、马约）获得优秀的博士后职位。我们的11名博士后候选人现已完成研究培训。其中六人是成功的学术研究人员，两人是生物技术公司的活跃研究人员（包括研究总监），一人在医学院工作。我们已成功地聘用了四个代表性不足的少数民族获得赠款，我们任命的人中有整整一半是妇女。合格的候选人，我们的培训师，优秀的核心设施，机构的承诺，以及广泛的科学专业知识的大量人才培养多学科的方法，这将确保我们的学员在科学事业的成功。

Description (provided by applicant): The current training program brings together twenty faculty members from a total of nine Departments on campus to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal of this grant is to train a mixture of M.D. and Ph.D. scientists with outstanding potential to develop a sustained, independent research program in these fields. Two predoctoral positions are requested to take advantage of the outstanding pool of M.D.- Ph.D. candidates and the long tradition of strong graduate programs at the University of Wisconsin. Fellows or residents in the Clinical Investigator track from the participating clinical Departments (Medicine, Pediatrics, Pathology, and Surgery) and Ph.D. trainees from the participating basic science departments (Anatomy, Biochemistry, Biostatistics, Microbiology, and Pharmacology) will be selected for the four postdoctoral positions. The faculty are a stable and interactive group that clusters in three major interest groups: basic and clinical aspects of hemostasis/inflammation, hematologic malignancies, and human stem cells/bone marrow transplantation. The faculty have broad expertise in both basic science and clinical sciences, including experimental approaches in gene arrays and genomics, transcriptional and post-transcriptional gene expression, protein structural analysis, proteomics, cell biology, hematopoetic and endothelial cell culture, murine animal models, primate and human embryonic stems cells, and bone marrow transplantation. There is a strong emphasis oh providing the multidisciplinary training required to pursue translational research opportunities, and the formal training of clinical investigators. Our training program takes advantage of the Clinical Investigator Preparatory Program (K30 grant) at the University of Wisconsin to provide didactic training in clinical trial design and biostatistics for candidates pursuing translational research projects. The program has an excellent record of retaining trainees in academic medicine. Of our eight predoctoral candidates, six continue in their Ph.D. degree program, and two have completed their degree and obtained excellent post-doctoral positions at outside institutions (Harvard, Mayo). Eleven of our postdoctoral candidates have now completed their research training. Six are successful academic researchers, two are active researchers in biotechnology companies (including a Director of Research), and one is in medical school. We have successfully recruited four under-represented minorities to the grant, and fully half of our appointees are women. The large pool of qualified candidates, outstanding mentorship abilities of our trainers, excellent core facilities, institutional commitment, and broad range of scientific expertise fosters multidisciplinary approaches that will ensure successful careers in science for our trainees.