Puerto Rico Testsite for Exploring Contamination Threats (PRoTECT)

波多黎各污染威胁探索试验场 (PRoTECT)

• 批准号: 8250025
• 负责人: Akram N Alshawabkeh
• 金额: $ 242.88万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-12 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8250025
• 关键词: Address; Biological; Biological Assay; Birth Rate; Chemicals; Complex; Data; Databases; Decision Making; Development; Disease; Environmental Exposure; Epidemiology; Etiology; Exposure to; Goals; Health; Healthy People 2010; Lead; Learning; Live Birth; Mining; Modeling; Oxidative Stress; Pathway interactions; Pattern; Pollution; Premature Birth; Process; Public Health; Puerto Rico; Risk Assessment; Risk Factors; Role; Sampling; Solvents; Strategic Planning; Superfund; Technology; Translating; United States; improved; indexing; innovation; interdisciplinary approach; new technology; phthalates; programs; remediation; research and development; superfund site

Preterm birth is a major health problem in the United States. In Puerto Rico, the preterm birth rate has increased to nearly 20% of live births and there is sufficient evidence that exposure to Superfund and related contaminants is a contributing factor. The theme of the PRoTECT Program is to use Puerto Rico as a testsite with dynamic exposure pathways through karstic aquifers to study Superfund and related contaminants and their contribution to preterm birth. The two goals of the Program are to: (1) Define the relationship between exposure to Superfund and related contaminants and preterm birth; and (2) Develop new technology for discovery, transport characterization, and green remediation of Superfund and related contaminants in karstic aquifers. To achieve these goals, the PRoTECT program will use a comprehensive, multidisciplinary approach that will ultimately lead to a better understanding of causal relationships between the exposures and preterm births, and will allow development of innovative remediation strategies to reduce short-term contaminant exposures, and long-term public health impacts. The five objectives of the Program are to: (1) Increase the evidence that Superfund and related contaminants contribute to preterm birth, identify the causative chemicals, and learn how to remediate these chemicals in karstic aquifers by a green process; (2) Build a better understanding of the potential role, mechanisms and relevance of pollution induced oxidative stress in preterm birth, (3) Discover and understand risk factors and their interactions for preterm birth by developing and mining an integrated, centralized, indexed data repository for Puerto Rico that includes epidemiological, hydrogeophysical, environmental fate and transport, and environmental exposure data, (4) Determine the effect of episodic transport on patterns of exposure through highly mobile karstic aquifers and develop adaptable remedial actions, and (5) Improve and apply nontargeted chemical analysis including bioassay-directed chemical analysis to biological samples and environmental samples. The PROTECT Program will conduct targeted and nontargeted studies to evaluate the contribution of exposure to Superfund and related contaminants to preterm birth. The targeted studies focus on chlorinated solvents and phthalates because they are suspect and model contaminants and because they are found in many Superfund sites in the US and Puerto Rico. The cross-disciplinary approach will employ the data-rich centralized data repository and integrated modeling/analysis capabilities to better understand complex interrelationships between multiple risk factors.

早产是美国的一个主要健康问题。在波多黎各，早产率已增加到近20%的活产，有足够的证据表明，接触超级基金和相关污染物是一个促成因素。PRoTECT计划的主题是将波多黎各作为 通过岩溶含水层的动态暴露途径，研究超级基金和相关污染物及其对早产的影响。该计划的两个目标是：（1）确定接触超级基金和相关污染物与早产之间的关系;（2）开发新技术，用于发现、运输表征和绿色补救岩溶含水层中的超级基金和相关污染物。为了实现这些目标，PRoTECT计划将使用全面的， 这将有助于采取多学科方法，最终更好地了解接触与早产之间的因果关系，并有助于制定创新的补救战略，以减少短期污染物接触和长期的公共健康影响。方案的五个目标 是：（1）增加超级基金和相关污染物导致早产的证据，确定致病化学物质，并了解如何通过绿色过程补救岩溶含水层中的这些化学物质;（2）更好地了解污染诱导的氧化应激在早产中的潜在作用、机制和相关性;（3）发现和了解风险因素及其相互作用， 通过开发和挖掘波多黎各的综合、集中、索引数据库，包括流行病学、水文地球物理、环境转归和迁移以及环境暴露数据，早产;（4）确定通过高度移动的， （5）改进和应用非目标化学分析，包括对生物样品和环境样品进行以生物测定为导向的化学分析。 该项目将进行有针对性和非有针对性的研究，以评估接触超级基金和相关污染物对早产的影响。目标研究重点关注氯化溶剂和邻苯二甲酸盐，因为它们是可疑和模型污染物，并且在美国和波多黎各的许多超级基金研究中心都发现了它们。跨学科方法将采用数据丰富的集中数据储存库和综合建模/分析能力，以更好地了解多种风险因素之间的复杂相互关系。