WV-INBRE:APPALACHIAN CARDIOVASCULAR RESEARCH NETWORK (ACORN)

WV-INBRE：阿巴拉契亚心血管研究网络 (ACORN)

• 批准号: 8360178
• 负责人: Donald Anthony Primerano
• 金额: $ 54.66万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360178
• 关键词: Adolescent Medicine; Appalachian Region; Award; Biological Markers; Biomedical Research; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cell physiology; Cholesterol; Chromosome Mapping; Communities; Coronary Arteriosclerosis; Databases; Death Rate; Diet; District of Columbia; Doctor of Philosophy; Endothelial Cells; Faculty; Familial Combined Hyperlipidemia; Fatty acid glycerol esters; Freedom; Funding; Gene Expression; Genetic; Genotype; Gifts; Goals; Grant; Health; Heart Diseases; Human; Institution; Institutional Review Boards; Kentucky; Lead; Leukocytes; Marshal; Mentors; Mentorship; Molecular Genetics; National Center for Research Resources; Nursing Research; Obesity; Participant; Patient Recruitments; Patients; Pattern; Principal Investigator; Protocols documentation; Regulation; Research; Research Infrastructure; Research Personnel; Resources; Role; Site; Source; Technology; Time; Triglycerides; USF1 gene; United States National Institutes of Health; Universities; West Virginia; base; cost; genetic resource; pediatrician; programs; research and development; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cardiovascular disease and obesity are significant health problems in West Virginia (WV) and Kentucky (KY). WV and KY rank 44th and 47th respectively in heart disease death rates and have the two highest rates of obesity (50th and 51st respectively) among the 50 states and the District of Columbia. The primary goals of the Appalachian Cardiovascular Research Network (ACoRN) are to (1) discover the molecular, genetic and environmental causes of cardiovascular disease, (2) provide mentorship, genetic resources and modern technology to faculty conducting cardiovascular research at the lead and undergraduate institutions in WV-INBRE and (3) support community based research in WV. The ACoRN team is directed by Donald Primerano PhD and consists of project investigators, consultants and mentors with expertise in genetic mapping, statistical genetics, genotyping and cardiovascular physiology. ACoRN will oversee or guide the following research studies on cardiovascular disease and provide mentorship to undergraduate project investigators: (a) Mechanism of Action of Statins on Endothelial Cell Function (SPID #25). P.I. Robert Kreisberg, West Liberty University. Mentor: N. Santanam, Marshall University. (b) Role of USF1 in the Regulation of Cholesterol and Triglyceride Synthesis (Faculty Research Development Award) Sarah Dodson, Fairmont State University. Mentor: D. Primerano. (c) The Genetic Basis of Familial Combined Hyperlipidemia (SPID #26). This project is directed by D. Primerano and requires the input of several experts within the WV-INBRE program: J. Denvir PhD, database manager, Yulia Dementieva, genetic analyst, William Neal MD cardiovascular pediatrician, and research nurses. (d) Dr. Sara Knox at West Virginia University is studying the effect of diet on gene expression patterns in human leukocytes and endothelial cells. (e) Epicardial Fat Biomarkers in Patients with Coronary Artery Disease in the Appalachian Region (SPID #36). Project Director N. Santanam PhD. Marshall University. In the WV-INBRE II, we will strengthen patient recruitment into human studies by (1) adding a full time recruitment coordinator to guide the research nurses, complete IRB protocols and fine tune recruitment strategies, (2) adding the Department of Adolescent Medicine at the University of Kentucky as a recruitment site, and (3) increasing the amount of participant gift cards to $30.

这个子项目是利用这些资源的众多研究子项目之一