WV-INBRE:APPALACHIAN CARDIOVASCULAR RESEARCH NETWORK (ACORN)

WV-INBRE：阿巴拉契亚心血管研究网络 (ACORN)

• 批准号: 8360178
• 负责人: Donald Anthony Primerano
• 金额: $ 54.66万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360178
• 关键词: Adolescent Medicine; Appalachian Region; Award; Biological Markers; Biomedical Research; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cell physiology; Cholesterol; Chromosome Mapping; Communities; Coronary Arteriosclerosis; Databases; Death Rate; Diet; District of Columbia; Doctor of Philosophy; Endothelial Cells; Faculty; Familial Combined Hyperlipidemia; Fatty acid glycerol esters; Freedom; Funding; Gene Expression; Genetic; Genotype; Gifts; Goals; Grant; Health; Heart Diseases; Human; Institution; Institutional Review Boards; Kentucky; Lead; Leukocytes; Marshal; Mentors; Mentorship; Molecular Genetics; National Center for Research Resources; Nursing Research; Obesity; Participant; Patient Recruitments; Patients; Pattern; Principal Investigator; Protocols documentation; Regulation; Research; Research Infrastructure; Research Personnel; Resources; Role; Site; Source; Technology; Time; Triglycerides; USF1 gene; United States National Institutes of Health; Universities; West Virginia; base; cost; genetic resource; pediatrician; programs; research and development; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cardiovascular disease and obesity are significant health problems in West Virginia (WV) and Kentucky (KY). WV and KY rank 44th and 47th respectively in heart disease death rates and have the two highest rates of obesity (50th and 51st respectively) among the 50 states and the District of Columbia. The primary goals of the Appalachian Cardiovascular Research Network (ACoRN) are to (1) discover the molecular, genetic and environmental causes of cardiovascular disease, (2) provide mentorship, genetic resources and modern technology to faculty conducting cardiovascular research at the lead and undergraduate institutions in WV-INBRE and (3) support community based research in WV. The ACoRN team is directed by Donald Primerano PhD and consists of project investigators, consultants and mentors with expertise in genetic mapping, statistical genetics, genotyping and cardiovascular physiology. ACoRN will oversee or guide the following research studies on cardiovascular disease and provide mentorship to undergraduate project investigators: (a) Mechanism of Action of Statins on Endothelial Cell Function (SPID #25). P.I. Robert Kreisberg, West Liberty University. Mentor: N. Santanam, Marshall University. (b) Role of USF1 in the Regulation of Cholesterol and Triglyceride Synthesis (Faculty Research Development Award) Sarah Dodson, Fairmont State University. Mentor: D. Primerano. (c) The Genetic Basis of Familial Combined Hyperlipidemia (SPID #26). This project is directed by D. Primerano and requires the input of several experts within the WV-INBRE program: J. Denvir PhD, database manager, Yulia Dementieva, genetic analyst, William Neal MD cardiovascular pediatrician, and research nurses. (d) Dr. Sara Knox at West Virginia University is studying the effect of diet on gene expression patterns in human leukocytes and endothelial cells. (e) Epicardial Fat Biomarkers in Patients with Coronary Artery Disease in the Appalachian Region (SPID #36). Project Director N. Santanam PhD. Marshall University. In the WV-INBRE II, we will strengthen patient recruitment into human studies by (1) adding a full time recruitment coordinator to guide the research nurses, complete IRB protocols and fine tune recruitment strategies, (2) adding the Department of Adolescent Medicine at the University of Kentucky as a recruitment site, and (3) increasing the amount of participant gift cards to $30.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 心血管疾病和肥胖是西弗吉尼亚州 (WV) 和肯塔基州 (KY) 的重大健康问题。西弗吉尼亚州和肯塔基州的心脏病死亡率分别排名第 44 位和第 47 位，并且在 50 个州和哥伦比亚特区中肥胖率最高（分别排名第 50 位和第 51 位）。 阿巴拉契亚心血管研究网络 (ACoRN) 的主要目标是 (1) 发现心血管疾病的分子、遗传和环境原因，(2) 为 WV-INBRE 领先和本科院校进行心血管研究的教师提供指导、遗传资源和现代技术，以及 (3) 支持西弗吉尼亚州的社区研究。 ACoRN 团队由 Donald Primerano 博士领导，由项目研究员、顾问和导师组成，他们在遗传图谱、统计遗传学、基因分型和心血管生理学方面拥有专业知识。 ACoRN 将监督或指导以下心血管疾病研究，并为本科项目研究人员提供指导： (a) 他汀类药物对内皮细胞功能的作用机制 (SPID #25)。 P.I.罗伯特·克莱斯伯格，西自由大学。导师：N. Santanam，马歇尔大学。 (b) USF1 在胆固醇和甘油三酯合成调节中的作用（教员研究发展奖）Sarah Dodson，费尔蒙特州立大学。导师：D. Primerano。 (c) 家族性混合性高脂血症的遗传基础 (SPID #26)。该项目由 D. Primerano 指导，需要 WV-INBRE 计划内的几位专家的投入：数据库经理 J. Denvir 博士、基因分析师 Yulia Dementieva、心血管儿科医生 William Neal MD 和研究护士。 (d) 西弗吉尼亚大学的 Sara Knox 博士正在研究饮食对人类白细胞和内皮细胞基因表达模式的影响。 (e) 阿巴拉契亚地区冠状动脉疾病患者的心外膜脂肪生物标志物 (SPID #36)。项目总监 N. Santanam 博士。马歇尔大学。 在 WV-INBRE II 中，我们将通过以下方式加强人体研究的患者招募：(1) 增加一名全职招募协调员来指导研究护士、完成 IRB 方案并微调招募策略；(2) 增加肯塔基大学青少年医学系作为招募地点；(3) 将参与者礼品卡的金额增加到 30 美元。