MULTI-PHOTON IMAGING OF ACTIN FILAMENT FORMATION AND MITOCHONDRIAL ENERGETICS

肌动蛋白丝形成和线粒体能量的多光子成像

基本信息

  • 批准号:
    8362658
  • 负责人:
  • 金额:
    $ 1.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-04-01 至 2012-03-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. PI will be developing multiphoton (MPM) optical imaging methods to systematically study human glioblastoma multiform spheroids embedded in various 3D ECMs. These experimental cancer model systems are used to mimic the in vivo gliomas. An MPM ratiometric redox fluorometry method based on intrinsic cellular fluorescence from reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavin adenine dinucleotide (FAD) to study mitochondrial energy metabolism will be developed by the PI. Coupling these finding with the evaluations of mitochondrial membrane using a dye and visualizing F-actin distribution in conjunction with mitochondrial signals will furnish a better understanding on how ECM alters the growth, differentiation and metabolic states of the malignant glioma cells. The imaging methods developed will help cancer investigators to study key cancer properties such as cell survival and metastasis and can allow accurate measurements of tumor response to treatments. The studies proposed will benefit current therapies and prognosis for glioblastoma multiform.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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TATIANA B KRASIEVA其他文献

TATIANA B KRASIEVA的其他文献

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{{ truncateString('TATIANA B KRASIEVA', 18)}}的其他基金

ROLE OF SMC COMPLEXES IN DNA REPAIR
SMC 复合物在 DNA 修复中的作用
  • 批准号:
    8362704
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:
BIO-POD: PALLET MICRO-ARRAY FOR RARE CELL ANALYSIS
BIO-POD:用于稀有细胞分析的托盘微阵列
  • 批准号:
    8362628
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:
MPM STUDY OF ANIMAL SYNOVIUM TO OBTAIN INSIGHT INTO AFFECTS OF ARTHRITIS
对动物滑膜进行 MPM 研究以深入了解关节炎的影响
  • 批准号:
    8362631
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:
IMAGING VULNERABLE PLAQUE IN ATHEROSCLEROTIC MICE
动脉粥样硬化小鼠中易损斑块的成像
  • 批准号:
    8362630
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:
NONINVASIVE IMAGING OF NEURAL STEM AND PRECURSOR CELL FUNCTIONS
神经干和前体细胞功能的无创成像
  • 批准号:
    8362632
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:
COMBINED TWO PHOTON OPTICAL COHERENCE MICROSCOPY FOR INTRAVITAL FUNCT IMAGING
用于活体功能成像的组合两个光子光学相干显微镜
  • 批准号:
    8362594
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:
ACBT GLIOMA SPHEROIDS
ACBT 胶质瘤球体
  • 批准号:
    8362626
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:
GENOME WIDE SIRNA SCREENING IDENTIFIES NOVEL REGULATORS OF MELANIN SECRETION
全基因组 SIRNA 筛选鉴定出黑色素分泌的新型调节因子
  • 批准号:
    8362629
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:
OPTICAL AND MOLECULAR APPROACHES TO THE STUDY OF CHEMICAL AGENTS
研究化学试剂的光学和分子方法
  • 批准号:
    8362624
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:
TRACHEAL CARTILAGE RESHAPING
气管软骨重塑
  • 批准号:
    8362636
  • 财政年份:
    2011
  • 资助金额:
    $ 1.03万
  • 项目类别:

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