TRACHEAL CARTILAGE RESHAPING

气管软骨重塑

• 批准号: 8362636
• 负责人: TATIANA B KRASIEVA
• 金额: $ 1.4万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362636
• 关键词: Anterior; Biotechnology; Cartilage; Devices; Funding; Germany; Grant; Inflammation; Lasers; Measures; Mechanics; Microscope; Morbidity - disease rate; National Center for Research Resources; New Zealand; Operative Surgical Procedures; Oryctolagus cuniculus; Principal Investigator; Property; Research; Research Infrastructure; Resources; Scanning; Source; Stenosis; Techniques; Testing; Tissue Viability; Tissues; United States National Institutes of Health; cost; design; dosimetry; instrument; repaired

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. INTRODUCTION:The usual surgical repair techniques (so-called "open technique") for anterior tracheal wall collapse are often associated with a high rate of morbidity, and prolonged stenting can aggravate the ongoing tracheal inflammation and serve as a potential source for a new stenosis. We are currently studying the laser dosimetry and the design of the surgical device for endoscopic laser cartilage reshaping minimizing the thermal damage of cartilage tissue. OBJECTIVE: In order to provide a better understanding of laser-induced tracheal cartilage reshaping, we examined the relationships between the tissue viability and the laser dosimetry as well as the change in mechanical property due to endoscopic laser exposure. In addition, we design an effective endoscopic surgical device for laser tracheal cartilage reshaping. MATERIALS AND METHODS: Tracheal cartilage extracted from New Zealand rabbits, were exposed to diode laser (wavelength =1450nm, 0.03-0.14W/mm2, Candela Corp. MA) for 3-5 seconds. The change in the mechanical property was measured using an ELF 3200 mechanical testing instrument (EnduraTEC, Minnetonka, MN) and its viability was determined using a laser scanning microscope (LSM510 Meta, Carl Zeiss Inc., Germany).

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 引言：气管前壁塌陷的常用手术修复技术（所谓的“开放技术”）通常与高发病率相关，长期支架植入可加重持续的气管炎症，并成为新狭窄的潜在来源。我们目前正在研究的激光剂量学和设计的内窥镜激光软骨整形手术装置，以尽量减少热损伤的软骨组织。目的：为了提供一个更好的理解激光诱导气管软骨重塑，我们研究了组织活力和激光剂量之间的关系，以及由于内窥镜激光照射的机械性能的变化。此外，我们设计了一种有效的内窥镜下激光气管软骨整形手术装置。材料和方法：将从新西兰兔中提取的气管软骨暴露于二极管激光（波长= 1450 nm，0.03-0.14W/mm 2，Canadian Corp. MA）3-5秒。使用ELF 3200机械测试仪器（EnduraTEC，明内通卡，MN）测量机械性能的变化，并使用激光扫描显微镜（LSM 510 Meta，Carl Zeiss Inc.，德国）。