MPM STUDY OF ANIMAL SYNOVIUM TO OBTAIN INSIGHT INTO AFFECTS OF ARTHRITIS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 退行性关节疾病是成年人身体残疾的最常见原因之一。早期诊断，确定退变阶段，监测关节表面对治疗的反应是必不可少的。如今，关节疾病的检测仅限于通过关节镜、X线片、CAT、MRI和超声波对关节表面进行可视化。所有这些技术都不能提供比100微米更好的分辨率。使用MPM(随着内窥镜的发展)对关节软骨/滑膜结构进行成像，可能会大大提高诊断的能力和准确性。 迈向最终目标的第一步是使用MPM研究动物关节并识别疾病迹象。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Degenerative joint disease is one of the most frequent causes of physical disability among adults. Early diagnosis, characterization of the stage of degeneration, and monitoring the response of articular surfaces to treatment is essential. Today, joint disease detection is limited to visualization of joint surfaces by arthroscopy, radiography, CAT, MRI and ultrasound. None of these techniques gives a resolution better that 100 micron. Using MPM (with the development of a endoscope) for imaging articular cartilage/synovial structure may provide significant benefit to diagnosing ability and accuracy. The first step toward the ultimate goal is to study animal joints using MPM and discern signs of disease.