MPM STUDY OF ANIMAL SYNOVIUM TO OBTAIN INSIGHT INTO AFFECTS OF ARTHRITIS

对动物滑膜进行 MPM 研究以深入了解关节炎的影响

• 批准号: 8362631
• 负责人: TATIANA B KRASIEVA
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362631
• 关键词: Adult; Affect; Animals; Arthritis; Arthroscopy; Biotechnology; Degenerative polyarthritis; Detection; Development; Diagnosis; Diagnostic radiologic examination; Disease; Early Diagnosis; Endoscopes; Funding; Goals; Grant; Image; Imagery; Joints; Lasers; Magnetic Resonance Imaging; Monitor; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resolution; Resources; Source; Staging; Structure; Surface; Synovial Membrane; Techniques; Ultrasonography; United States National Institutes of Health; arthropathies; articular cartilage; cost; disability; insight; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Degenerative joint disease is one of the most frequent causes of physical disability among adults. Early diagnosis, characterization of the stage of degeneration, and monitoring the response of articular surfaces to treatment is essential. Today, joint disease detection is limited to visualization of joint surfaces by arthroscopy, radiography, CAT, MRI and ultrasound. None of these techniques gives a resolution better that 100 micron. Using MPM (with the development of a endoscope) for imaging articular cartilage/synovial structure may provide significant benefit to diagnosing ability and accuracy. The first step toward the ultimate goal is to study animal joints using MPM and discern signs of disease.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 退行性关节病是成人身体残疾的最常见原因之一。早期诊断、退变阶段的表征以及监测关节面对治疗的反应至关重要。如今，关节疾病检测仅限于通过关节镜检查、放射线照相、CAT、MRI 和超声波对关节表面进行可视化。这些技术均无法提供优于 100 微米的分辨率。使用 MPM（随着内窥镜的发展）对关节软骨/滑膜结构进行成像可能会显着提高诊断能力和准确性。 实现最终目标的第一步是使用 MPM 研究动物关节并辨别疾病迹象。