Cardiac Remodeling, Signaling, Matrix and Heart Function

描述(由申请人提供)：申请支持由Anthony J.Muslin、Jil C.Tardiff和Steven R.Houser组织的题为心脏重塑、信号、矩阵和心脏功能的Keystone研讨会。会议将于2013年4月7日至12日在犹他州雪鸟举行。本次会议的总议题涉及导致心力衰竭和心律失常发展的解剖和生理变化。更具体地说，它将突出心脏生物学和心力衰竭研究的最新科学进展，并将这些见解与可能影响患者护理的新型临床疗法的开发联系起来。这次为期4天的会议将汇集学术和工业科学家，他们使用最先进的技术，涵盖干细胞科学、组织再生、生物工程、非编码RNA、人类和动物遗传学、钙信号、自噬和蛋白质分解、心脏力学和心脏基质生物学等领域。将强调将基础科学发现转化为临床前药物开发。此外，还将举办一个研讨会，详细介绍治疗心力衰竭和心律失常的新型治疗剂开发的最新进展。举办这次Keystone研讨会的目的是为科学家提供不同领域的专业知识、技术应用知识和关于心脏功能障碍和心律失常的发展和病理生理学的生物学见解。科学家之间的互动将通过讲座、海报会议、非正式讨论和研讨会在高度有利于相声的环境中得到促进。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Cardiac Remodeling, Signaling, Matrix and Heart Function, organized by Anthony J. Muslin, Jil C. Tardiff and Steven R. Houser. The meeting will be held in Snowbird, Utah from April 7 - 12, 2013. The general topic of this meeting pertains to anatomic and physiologic changes that contribute to the development of heart failure and cardiac arrhythmias. More specifically, it will highlight recent scientific advances in cardiac biology and heart failur research and relate these insights to the development of novel clinical therapeutics that may impact patient care. This 4-day meeting will bring together both academic and industrial scientists employing state-of-the-art technologies encompassing the fields of stem cell science, tissue regeneration, bioengineering, non-coding RNAs, human and animal genetics, calcium signaling, autophagy and proteolysis, cardiac mechanics, and cardiac matrix biology. The translation of basic scientific discovery to pre-clinical drug development will be emphasized. In addition, there will be a workshop that details recent advances in development of novel therapeutic agents to treat heart failure and arrhythmias. This Keystone Symposia meeting is organized to provide scientists with diverse areas of expertise knowledge of technological applications and biological insights about the development and pathophysiology of cardiac dysfunction and arrhythmias. Interaction between scientists will be promoted through lectures, poster sessions, informal discussions and workshops in an environment that is highly conducive to cross-talk.