Cardiac Remodeling, Signaling, Matrix and Heart Function

心脏重塑、信号传导、基质和心脏功能

• 批准号: 8527455
• 负责人: DAVID L. WOODLAND
• 金额: $ 1.38万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8527455
• 关键词: Academia; Address; Anatomy; Animal Genetics; Area; Arrhythmia; Autophagocytosis; Biological; Biology; Biomedical Engineering; Biomedical Research; Biophysics; Calcium Signaling; Cardiac; Cardiomyopathies; Cells; Cellular biology; Clinical; Clinical Drug Development; Collaborations; Communities; Development; Developmental Biology; Discipline; Disease; Educational workshop; Environment; Extracellular Matrix; Functional RNA; Functional disorder; Genetic; Heart; Heart failure; Human Genetics; Individual; Industry; Knowledge; Lead; Mechanics; MicroRNAs; Modality; Molecular; Morbidity - disease rate; Natural regeneration; Outcome; Patient Care; Patients; Physiological; Proteolysis; Regulation; Research; Role; Science; Scientific Advances and Accomplishments; Scientist; Signal Pathway; Signal Transduction; Stem cells; Structure; Students; Syndrome; Technology; Therapeutic; Therapeutic Agents; Translations; Utah; Workplace; heart function; improved; insight; lectures; meetings; mortality; novel; novel therapeutic intervention; novel therapeutics; outcome forecast; posters; pre-clinical; public health relevance; symposium; tissue regeneration; transdifferentiation

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Cardiac Remodeling, Signaling, Matrix and Heart Function, organized by Anthony J. Muslin, Jil C. Tardiff and Steven R. Houser. The meeting will be held in Snowbird, Utah from April 7 - 12, 2013. The general topic of this meeting pertains to anatomic and physiologic changes that contribute to the development of heart failure and cardiac arrhythmias. More specifically, it will highlight recent scientific advances in cardiac biology and heart failur research and relate these insights to the development of novel clinical therapeutics that may impact patient care. This 4-day meeting will bring together both academic and industrial scientists employing state-of-the-art technologies encompassing the fields of stem cell science, tissue regeneration, bioengineering, non-coding RNAs, human and animal genetics, calcium signaling, autophagy and proteolysis, cardiac mechanics, and cardiac matrix biology. The translation of basic scientific discovery to pre-clinical drug development will be emphasized. In addition, there will be a workshop that details recent advances in development of novel therapeutic agents to treat heart failure and arrhythmias. This Keystone Symposia meeting is organized to provide scientists with diverse areas of expertise knowledge of technological applications and biological insights about the development and pathophysiology of cardiac dysfunction and arrhythmias. Interaction between scientists will be promoted through lectures, poster sessions, informal discussions and workshops in an environment that is highly conducive to cross-talk.

描述（由申请人提供）：要求对由Anthony J. Muslin、Jil C.作者声明：Steven R.豪泽会议将于2013年4月7日至12日在犹他州的雪鸟举行。本次会议的一般主题涉及导致心力衰竭和心律失常发展的解剖学和生理学变化。更具体地说，它将突出心脏生物学和心力衰竭研究的最新科学进展，并将这些见解与可能影响患者护理的新型临床治疗方法的发展联系起来。这次为期4天的会议将汇集学术和工业科学家，采用最先进的技术，涵盖干细胞科学，组织再生，生物工程，非编码RNA，人类和动物遗传学，钙信号，自噬和蛋白水解，心脏力学和心脏基质生物学领域。将强调基础科学发现转化为临床前药物开发。此外，还将举办一个研讨会，详细介绍治疗心力衰竭和心律失常的新型治疗药物的最新进展。本次Keystone研讨会旨在为科学家提供不同领域的专业知识、技术应用知识以及有关心功能障碍和心律失常的发展和病理生理学的生物学见解。将通过讲座、张贴海报、非正式讨论和在非常有利于交流的环境中举办讲习班来促进科学家之间的互动。