National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA): SRI

描述（由申请人提供）：为了响应RFA-AA-12-006，本申请提议由国家青少年酒精和神经发育联盟（n - canada）的SRI国际研究组成部分来确定酒精使用对青少年大脑发育的影响。招募年龄在12至21岁之间的170名SRI受试者（来自所有站点的N=680）的高风险增强社区样本将完成基线评估，并在加速纵向设计中进行三次年度随访评估。在每次访问时，将测量多模态磁共振成像（MRI）方案、综合神经心理学电池、酒精和其他物质使用及相关问题、精神健康症状学和物质使用障碍风险因素的评估。脑成像包括最先进的高分辨率结构MRI （sMRI）、扩散张量成像（DTI）和静息状态MRI （rsMRI）。对酒精后果的检查将集中在青春期积极发育的大脑区域的结构和功能成熟上，这些区域涉及心理调节，对奖励作出反应，并被认为容易受到酒精的不良影响。此外，SRI研究部分将在另外两项研究上进行合作。我们将与匹兹堡大学合作开展一项实验室睡眠研究，研究青少年大量饮酒对睡眠脑电图（EEG）发育轨迹的影响，这是一种新的、敏感的脑功能完整性标志物。我们也会

DESCRIPTION (provided by applicant): In response to RFA-AA-12-006, this application proposes the SRI International Research Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (N-CANDA) to determine the effects of alcohol use on the developing adolescent brain. Recruited at ages 12 through 21, a high risk enhanced community sample of 170 SRI subjects (N=680 from all sites) will complete a baseline assessment and undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal magnetic resonance imaging (MRI) protocol, comprehensive neuropsychological battery, and assessments of alcohol and other substance use and related problems, mental health symptomatology, and substance use disorder risk factors will be measured. Brain imaging includes state-of-the-art high resolution structural MRI (sMRI), diffusion tensor imaging (DTI), and resting state MRI (rsMRI). The examination of alcohol consequences will focus on structural and functional maturation of brain areas that are actively developing during adolescence, involved in psychological regulation, responsive to rewards, and thought to be vulnerable to untoward alcohol effects. In addition, the SRI Research Component will collaborate on two additional studies. We will collaborate with Pittsburgh in a laboratory sleep study to examine the effects of adolescent heavy drinking on developmental trajectories of sleep EEG, a novel and sensitive marker of functional brain integrity. We will also collaborate with UCSD to study the effects of adolescent heavy drinking on default mode network integrity, and the extent to which this mediates cognitive performance, using functional connectivity analysis of data acquired in an fMRI protocol conducted during a Stroop Match-to-Sample Task. Studied in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at heightened risk for an alcohol use disorder.