National Consortium on Alcohol and NeuroDevelopment in Adolescence - SRI International Research Project Site (NCANDA-SRI)

项目摘要/摘要 众所周知，在青春期开始过量饮酒会扰乱典型的神经发育模式， 增加患酒精使用障碍(AUD)的风险，并加速成年后的更年期过程。 响应RFA-AA-21-007，本申请提出了国家联合体的研究项目站点 关于酒精与青春期-成年期神经发育(NCANDA-A)未来5年的研究 在三个年龄段(12-14、15-17、18-21)招募的男性和女性参与者的不同社区样本 5岁)，当时大多数人不喝酒或不喝酒，并在过去8年中跟踪调查了5个地点(N=831；93%) 保留率)。监测涉及每年获得的多模式神经成像(MRI、DTI、静息状态 FMRI、任务fMRI)、认知、临床、行为和生物数据，亲自或通过计算机远程收集 还有我们的移动应用程序。这些措施现在将得到新的先进的神经成像和睡眠的补充 和体力活动跟踪。这一队列顺序设计独特地将NCANDA-A定位为量化瞬变 或在特定的青春期和成年早期神经系统发育轨迹中忍受与酒精相关的障碍 以及功能上的伴随。 NCANDA-A提出了四个联合体范围的具体目标和两个专业项目目标。在目标1中，NCANDA-A 将调查青春期和成年初期过度饮酒对 认知表现、大脑结构和功能的后续发展轨迹，以及 精神变态学。目标2的分析将确定神经发育模式，描述 酒精对大脑结构和功能的影响在酗酒后的戒酒过程中会消失或持续。目标3 将部署数据驱动分析，以确定青少年的生物、环境和行为因素(例如，年龄 饮酒开始)，这预示着在成年早期过度饮酒。在目标4中，NCANDA-A将量化 新冠肺炎大流行对生活压力、社会、情绪和经济福祉及其关系的影响 与酒精使用模式有关。在目标5中，SRI和匹兹堡站点将确定以下模式之间的相互作用 饮酒、睡眠和心脏功能。在目标6中，加州大学圣地亚哥分校、杜克大学和职业卫生与健康教育学院的网站将决定 短期(即4周)停止饮酒会导致认知、情感、 睡眠和静息心率，逆转频繁暴饮暴食对大脑结构和功能的不利影响 酗酒。对于每个目标，发育中的性别差异、酒精使用模式和历史、酒精的影响 对大脑的使用，以及性别差异的心理社会因素将进行测试。 随着在这次更新中收集到成年早期的纵向数据，NCANDA-A将提供新的 向公众提供有关青少年饮酒对成年人机能的持久和短暂影响的信息 发现链接这些动态过程的要素和机制，并确定可更改的风险因素。

PROJECT SUMMARY / ABSTRACT Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of male and female participants recruited in three age bands (12-14, 15-17, 18-21 years old) when most were no-to-low drinkers and tracked over the last 8 years across 5 sites (N=831; 93% retention rate). Monitoring has involved annually acquired multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which alcohol's effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3 will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age of drinking onset) that forecast excessive drinking during early adulthood. In Aim 4, NCANDA-A will quantify the impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors will be tested. With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information to the public on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.