Investigation of the role of the GPIb/V/IX-filamin-1 interaction in regulating platelet function in vivo

GPIb/V/IX-filamin-1 相互作用在体内调节血小板功能中的作用研究

• 批准号: nhmrc : 237010
• 负责人: Prof Shaun Jackson
• 金额: $ 17.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-role-gpibvix-function-vivo/76364
• 关键词: Investigation; role; GPIb; IX; filamin

Platelets play an essential role in blood clotting and blod vessel repair. Upon injury to a blood vessel, platelets rapidly adhere to the area of damage where they undergo dramatic changes in their shape and internal structure that facilitates spreading over the area of injury and subsequent formation of a stable blood clot. Our research studies are aimed at understanding more closely the factors that regulate the adhesiveness of platelets, since this is an important determinant not only in normal blood clot formation but also in the development of harmful blood clots (thrombosis) associated with the development of diseases such as heart attack and stroke. Our particular focus is on the interaction between adhesion receptors on the surface of the platelet and components of the intracellular platelet structure referred to as the cytoskeleton and how this interaction might regulate the reactivity of platelets and their ability to adhere to blood vessels. We believe this may be an important mechanism that regulates platelet adhesion and notmal blood clotting.

血小板在血液凝固和血管修复中起重要作用。在血管损伤后，血小板迅速粘附到损伤区域，在那里它们的形状和内部结构发生显著变化，这有助于在损伤区域上扩散并随后形成稳定的血凝块。我们的研究旨在更深入地了解调节血小板活化的因素，因为这不仅是正常血凝块形成的重要决定因素，而且也是与心脏病发作和中风等疾病发展相关的有害血凝块（血栓形成）的重要决定因素。我们特别关注的是血小板表面粘附受体与细胞内血小板结构（称为细胞骨架）组分之间的相互作用，以及这种相互作用如何调节血小板的反应性及其粘附血管的能力。我们认为这可能是调节血小板粘附和正常凝血的重要机制。