Investigations into the biology and functionality of the human T cell receptor

人类 T 细胞受体的生物学和功能研究

• 批准号: nhmrc : 613664
• 负责人: A/Pr John Miles
• 金额: $ 28.29万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigations-biology-functionality-cell-receptor/78320
• 关键词: Investigations; into; biology; functionality; human

T lymphocytes play a pivotal role in the immune system by recognising virus-infected tissue and tumour cells through the use of specific cell surface receptors called T cell receptors (TCR). This project will study why partcular TCRs are used by the immune system, and will also examine the specificity of T cell recognition by determine the range of molecules an individual T cell can recognise. The work will aid in the development of new intelligent vaccines for cancer and infectious disease.

T淋巴细胞通过使用称为T细胞受体（TCR）的特异性细胞表面受体识别病毒感染的组织和肿瘤细胞，在免疫系统中发挥关键作用。该项目将研究为什么免疫系统使用特定的TCR，并通过确定单个T细胞可以识别的分子范围来检查T细胞识别的特异性。这项工作将有助于开发癌症和传染病的新型智能疫苗。