The role of long peptide epitopes in antiviral CD8+ T cell recognition.

长肽表位在抗病毒 CD8 T 细胞识别中的作用。

• 批准号: nhmrc : 1021620
• 负责人: A/Pr John Miles
• 金额: $ 28.98万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-long-peptide-cell-recognition/110137
• 关键词: role; long; peptide; epitopes; antiviral

The immune response to viral infection involves killer T cell recognition of small viral peptides presented by infected cells. Researchers have been attempting to identify the viral peptides that are recognised by T cells. Although these studies have been successful, the major aim of this project is to investigate if the role of unusually long peptides has been underestimated. This project should lead to enhanced monitoring of immune responses and improvements in vaccine design.

对病毒感染的免疫应答涉及杀伤T细胞识别由感染细胞呈递的小病毒肽。研究人员一直试图识别T细胞识别的病毒肽。虽然这些研究已经取得了成功，但该项目的主要目的是调查异常长肽的作用是否被低估。这一项目将加强对免疫反应的监测，并改进疫苗设计。