Understanding and modulating the human immune system

了解和调节人体免疫系统

• 批准号: nhmrc : GNT1131732
• 负责人: A/Pr John Miles
• 金额: $ 47.01万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-modulating-human-immune/1347826
• 关键词: Understanding; modulating; human; immune; system

T cells are the sentinels of our immune system continually scanning our tissue for abnormalities and eliminating threats in many forms. They are our second and last line of defence against microorganisms and cancer. Unfortunately, T cells can also cause harm through accidental crossreactvity or overzealous function. My work is directed at understanding how T cells work and how they can be controlled using drugs and gene therapy. If we can ‘tune’ the power of this master immune lineage we can unl

T细胞是我们免疫系统的哨兵，不断扫描我们的组织以发现异常并消除多种形式的威胁。它们是我们抵御微生物和癌症的第二道也是最后一道防线。不幸的是，T细胞也可以通过意外的交叉反应或过度的功能造成伤害。我的工作是了解T细胞如何工作，以及如何使用药物和基因治疗来控制它们。如果我们能“调整”这种免疫谱系的力量，