Determining the biological significance of allelic sequence variation within the T cell receptor loci

确定 T 细胞受体基因座内等位基因序列变异的生物学意义

• 批准号: nhmrc : 1067374
• 负责人: A/Pr John Miles
• 金额: $ 41.85万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-biological-significance-receptor-loci/455303
• 关键词: Determining; biological; significance; allelic; sequence

T lymphocytes play a pivotal role in the immune system by recognising virus-infected tissue through the use of highly specific T cell receptors (TCRs). This project will investigate the importance of genetic variation in the TCR genes in influencing how we fight infections. Advances in these areas will assist in understanding susceptibility to some autoimmune diseases as well as aiding in the development of new "intelligent" vaccines and individualised therapeutics.

T淋巴细胞通过使用高度特异性的T细胞受体（TCR）识别病毒感染的组织，在免疫系统中发挥关键作用。该项目将研究TCR基因中的遗传变异在影响我们如何对抗感染方面的重要性。这些领域的进展将有助于了解对某些自身免疫性疾病的易感性，并有助于开发新的“智能”疫苗和个性化治疗方法。