A new approach to the design and evaluation of T cell vaccines for cancer and infectious disease.

一种设计和评估癌症和传染病 T 细胞疫苗的新方法。

• 批准号: nhmrc : 1078987
• 负责人: A/Pr John Miles
• 金额: $ 26.28万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-approach-design-infectious-disease/518624
• 关键词: new; approach; design; evaluation; cell

Special white blood cells called dendritic cells teach the immune system to fight cancer and are a key component of therapeutic cancer vaccines. We identified a subtype of human dendritic cell that is predicted to be the most effective at mounting anti-cancer immune responses. We developed a novel antibody specific for these dendritic cells that can be used to deliver the vaccine directly to them and will use this to construct and validate a novel vaccine for cancer and viral infections.

被称为树突状细胞的特殊白细胞教导免疫系统与癌症抗争，是治疗性癌症疫苗的关键组成部分。我们确定了人类树突状细胞的一种亚型，据预测，这种亚型在增强抗癌免疫反应方面最有效。我们开发了一种针对这些树突状细胞的新抗体，可以用来直接将疫苗传递给它们，并将使用它来构建和验证一种新的癌症和病毒感染疫苗。