Development of CD96 antibodies for cancer treatment
Development of CD96 antibodies for cancer treatment
批准号:
nhmrc : 1093566
负责人:
A/Pr John Miles
金额:
$54.73万
依托单位国家:
澳大利亚
项目类别:
Development Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
There is an unmet medical need to develop new immunotherapies that are safer and potentially allow the treatment of a broader range of cancers. Inhibiting the immune checkpoint CD96 function represents an opportunity that may parallel and indeed complement the activity and impact of other lymphocyte checkpoint inhibitors in human cancer (eg. CTLA-4 and PD1/PD-L1). While developing a new human therapeutic antibody we will also learn more about an important checkpoint in the immune response.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
-
批准号:nhmrc : 1125141
-
项目类别:Project Grants
-
资助金额:$42.47万
-
财政年份:2017
-
负责人:A/Pr John Miles
-
依托单位:
Understanding and modulating the human immune system
-
批准号:nhmrc : GNT1131732
-
项目类别:Career Development Fellowships
-
资助金额:$47.01万
-
财政年份:2017
-
负责人:A/Pr John Miles
-
依托单位:
Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease
-
批准号:nhmrc : GNT1125141
-
项目类别:Project Grants
-
资助金额:$62.24万
-
财政年份:2017
-
负责人:A/Pr John Miles
-
依托单位:
Understanding and modulating the human immune system
-
批准号:nhmrc : 1131732
-
项目类别:Career Development Fellowships
-
资助金额:$32.12万
-
财政年份:2017
-
负责人:A/Pr John Miles
-
依托单位:
Defining the molecular and functional features of protective HIV-specific T cells
-
批准号:nhmrc : 1106756
-
项目类别:Project Grants
-
资助金额:$40.59万
-
财政年份:2016
-
负责人:A/Pr John Miles
-
依托单位:
Defining the molecular and functional features of protective HIV-specific T cells
-
批准号:nhmrc : GNT1106756
-
项目类别:Project Grants
-
资助金额:$59.2万
-
财政年份:2016
-
负责人:A/Pr John Miles
-
依托单位:
A new approach to the design and evaluation of T cell vaccines for cancer and infectious disease.
-
批准号:nhmrc : 1078987
-
项目类别:Project Grants
-
资助金额:$26.28万
-
财政年份:2015
-
负责人:A/Pr John Miles
-
依托单位:
Tracking the human immune system over years of life
-
批准号:nhmrc : GNT1069281
-
项目类别:Project Grants
-
资助金额:$45.64万
-
财政年份:2014
-
负责人:A/Pr John Miles
-
依托单位:
Determining the biological significance of allelic sequence variation within the T cell receptor loci
-
批准号:nhmrc : 1067374
-
项目类别:Project Grants
-
资助金额:$41.85万
-
财政年份:2014
-
负责人:A/Pr John Miles
-
依托单位:
Following the T cell repertoire over the human life course
-
批准号:nhmrc : 1069281
-
项目类别:Project Grants
-
资助金额:$31.55万
-
财政年份:2014
-
负责人:A/Pr John Miles
-
依托单位:
Tracking the impact of superinfection with a common Herpesvirus on T cell immunity in humans
-
批准号:nhmrc : 1045870
-
项目类别:Project Grants
-
资助金额:$21.19万
-
财政年份:2013
-
负责人:A/Pr John Miles
-
依托单位:
Investigations into supraphysiologic T cell receptors and T cell agonists.
-
批准号:nhmrc : 1031652
-
项目类别:Career Development Fellowships
-
资助金额:$27.23万
-
财政年份:2012
-
负责人:A/Pr John Miles
-
依托单位:
The role of long peptide epitopes in antiviral CD8+ T cell recognition.
-
批准号:nhmrc : 1021620
-
项目类别:Project Grants
-
资助金额:$28.98万
-
财政年份:2012
-
负责人:A/Pr John Miles
-
依托单位:
Investigations into the biology and functionality of the human T cell receptor
-
批准号:nhmrc : 613664
-
项目类别:NHMRC Project Grants
-
资助金额:$28.29万
-
财政年份:2010
-
负责人:A/Pr John Miles
-
依托单位:
Investigations into the architectural and biophysical features of optimal T cell receptor design
-
批准号:nhmrc : 496721
-
项目类别:Early Career Fellowships
-
资助金额:$16.8万
-
财政年份:2008
-
负责人:A/Pr John Miles
-
依托单位:
Investigations into the cytolytic T cell response during Epstein-Barr virus related disease
-
批准号:nhmrc : 389937
-
项目类别:NHMRC Postgraduate Scholarships
-
资助金额:$0.25万
-
财政年份:2006
-
负责人:A/Pr John Miles
-
依托单位:
Cytotoxic T lymphocyte response to Epstein-Barr virus
-
批准号:nhmrc : 339480
-
项目类别:NHMRC Postgraduate Scholarships
-
资助金额:$2.81万
-
财政年份:2005
-
负责人:A/Pr John Miles
-
依托单位:
国内基金
海外基金
登录
查看更多内容
FOXP3通过激活PVR/TIGIT、PVR/CD96信号轴抑制免疫细胞功能促进肺腺癌的发生发展
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2023
-
负责人:杨书才
-
依托单位:
BCL11B调控CD226/CD96分子逆转高危MDS中T细胞耗竭的机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2023
-
负责人:黄欣
-
依托单位:
实体肿瘤固有CD96通过调控肿瘤干细胞促进化疗耐药的机制探讨
-
批准号:82203867
-
项目类别:青年科学基金项目(C类)
-
资助金额:20.0万元
-
批准年份:2022
-
负责人:黎江
-
依托单位:
UV通过新型免疫检查点通路CD155-TIGIT/CD96/CD226轴介导CD8+T细胞功能耗竭诱发真皮免疫微环境失衡的日光致皮肤恶性肿瘤调控及机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:郑跃
-
依托单位:
NK细胞抑制性受体CD96作为肝癌checkpoint免疫治疗靶点的进一步验证
-
批准号:81972679
-
项目类别:面上项目
-
资助金额:60.0万元
-
批准年份:2019
-
负责人:孙昊昱
-
依托单位:
NK细胞活化性受体CD96介导的信号途径研究
-
批准号:30771964
-
项目类别:面上项目
-
资助金额:8.0万元
-
批准年份:2007
-
负责人:朱参胜
-
依托单位: