Using Methods in Genetic Epidemiology to Elucidate the Relationship Between Viral Infection and Risk of Autoimmune Disease

利用遗传流行病学方法阐明病毒感染与自身免疫性疾病风险之间的关系

• 批准号: nhmrc : 1125141
• 负责人: A/Pr John Miles
• 金额: $ 42.47万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-methods-genetic-autoimmune-disease/947512
• 关键词: Using; Methods; Genetic; Epidemiology; Elucidate

Autoimmune diseases occur when the body's natural defense mechanisms attack healthy tissues by mistake. It has long been thought that viral infections might play a role in triggering autoimmune disease. Our study aims to find genes that influence the body's response to viral infection and subsequently whether the same genes are involved in autoimmune disease pathology. If the same genes are important in both situations then this will provide evidence that viruses trigger autoimmune disease.

当身体的自然防御机制错误地攻击健康组织时，就会发生自身免疫性疾病。长期以来，人们一直认为病毒感染可能在引发自身免疫性疾病方面发挥作用。我们的研究旨在发现影响身体对病毒感染反应的基因，以及随后是否相同的基因参与自身免疫性疾病的病理学。如果相同的基因在这两种情况下都很重要，那么这将提供病毒引发自身免疫性疾病的证据。