ABCD-USA Consortium: Twin Research Project

ABCD-美国联盟：双胞胎研究项目

• 批准号: 9054255
• 负责人: Marie T Banich
• 金额: $ 264.15万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9054255
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adolescent Development; Adult; Affect; Age; Alcohol consumption; Alcohol or Other Drugs use; Behavior; Behavioral; Behavioral Genetics; Biochemical Markers; Biological; Biological Assay; Brain; Brain imaging; Brain scan; Child; Clinical; Cognitive; Colorado; Communities; Consent; Data; Data Analyses; Demographic Factors; Development; Dizygotic Twins; Drug abuse; Drug usage; Emotional; Enrollment; Environment; Event; Feces; Frequencies; Functional Magnetic Resonance Imaging; Future; Genes; Genetic; Genetic study; Genomics; Growth; Health; Hormonal Change; Image; Individual; Informatics; Institutes; Interview; Investigation; Life; Link; Longitudinal Studies; Magnetic Resonance Imaging; Marijuana; Mediating; Mental Health; Methodology; Methods; Minnesota; Modeling; Monitor; Motivation; Neurobiology; Neurocognitive; Neuropsychological Tests; Nicotine; Online Systems; Outcome; Outcome Measure; Participant; Pathology; Pathway interactions; Pattern; Phenotype; Prevention; Process; Psyche structure; Psychopathology; Puberty; Public Policy; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Rewards; Risk; Risk-Taking; Saliva; Sampling; Self-control as a personality trait; Serum; Site; Social Functioning; Source; Structure; Symptoms; Techniques; Technology; Teenagers; Testing; Time; Toxic effect; Twin Multiple Birth; Universities; Urine; Virginia; Washington; Work; addiction; adolescent substance use; aged; base; behavioral health; behavioral outcome; cognitive control; design; early onset substance use; endophenotype; epigenomics; follow-up; gene environment interaction; genome sequencing; gut microbiota; innovation; interest; metabolomics; microbiome; misuse of prescription only drugs; neurocognitive test; neuroimaging; peer influence; physical conditioning; psychological outcomes; public health relevance; relating to nervous system; response; temporal measurement; trend

 DESCRIPTION (provided by applicant): Adolescence is a critical neurodevelopmental period associated with dramatic increases in rates of substance use. Identifying the pathways to substance use and its effects on adolescent development is critically important, as the effects of substance use during ongoing maturation likely have long-lasting effects on brain functioning and behavioral, health, and psychological outcomes. This Research Project Site application from the Twin Hub of the ABCD-USA Consortium is in response to RFA-DA-15-015; the proposal includes the University of Minnesota (hub leader), Virginia Commonwealth University, Washington University, and the University of Colorado to prospectively determine neurodevelopmental and behavioral predictors and consequences of substance use on children and adolescents. A representative community sample of 800 twin pairs, ages 9-10 years, from four sites whose researchers are leaders in twin research, SU and abuse, and neuroimaging of cognitive and emotional functioning will be tested, together with 700 singletons, contributing to the sample of 11,111 to be collected from 11 hubs across the ABCD-USA Consortium. Participants will undergo a comprehensive baseline assessment, including state-of-the-art brain imaging, comprehensive neuropsychological testing, bioassays, mobile monitoring and careful assessment of substance use, environment, psychopathological symptoms, and social functioning every 2 years. Interim annual interviews and quarterly web-based assessments will provide refined temporal resolution of behaviors, development, and life events with minimal participant burden. These Consortium-wide data obtained during the course of this project will elucidate: 1) effects of substance use patterns on the adolescent brain; 2) effects of substance use on behavioral and health outcomes; 3) bidirectional relationships between psychopathology and substance use patterns; 4) effects of individual genetic, behavioral, neurobiological, and environmental differences on risk profiles and substance use outcomes; and 5) "gateway interactions" between use of different substances. The Twin Hub proposes to use classic and co-twin control designs to study genetic vs. environmental contributions to adolescent brain/behavioral development and how these contributions predict SU propensity. Using sophisticated growth trajectory modeling techniques, we will also identify the genetic and environmentally- determined consequences of substance use on brain and behavioral development, including the assessment of gene-by-environment interactions. In addition, we will develop biospecimen resources for future studies of genomic, epigenomic, metabolomics and microbiome changes that may influence substance use and its broad health consequences. Specific to this Twin-Hub, we will obtain baseline and follow-up serum, saliva, and in some cases gut microbiota from biological samples. This work enriches the full ABCD-USA Consortium given that disentangling G and E contributions to individual risk for addiction and sensitivity to SU's neurocognitive effects has highly significant public policy and prevention-based implications.

 描述(由申请人提供)：青春期是神经发育的关键时期，与物质使用率的急剧增加有关。确定物质使用的途径及其对青少年发展的影响至关重要，因为正在进行的成熟期物质使用的影响可能会对大脑功能和行为、健康和心理结果产生长期影响。ABCD-USA联盟Twin Hub的这项研究项目现场申请是对RFA-DA-15-015的响应；该提案包括明尼苏达大学(中心负责人)、弗吉尼亚联邦大学、华盛顿大学和科罗拉多大学，以前瞻性地确定儿童和青少年使用药物的神经发育和行为预测因素和后果。来自四个网站的800对9-10岁双胞胎的代表性社区样本将与700名单身人士一起接受测试，这些网站的研究人员在双胞胎研究、SU和虐待以及认知和情绪功能的神经成像方面处于领先地位，将从ABCD-USA联盟的11个中心收集11,111个样本。参与者将每两年接受一次全面的基线评估，包括最先进的大脑成像、全面的神经心理测试、生物测试、移动监测和对物质使用、环境、精神病理症状和社会功能的仔细评估。临时年度访谈和基于网络的季度评估将以最小的参与者负担提供行为、发展和生活事件的精细化时间解决方案。在本项目过程中获得的这些联盟范围的数据将阐明：1)物质使用模式对青少年大脑的影响；2)物质使用对行为和健康结果的影响；3)精神病理学和物质使用模式之间的双向关系；4)个体遗传、行为、神经生物学和环境差异对风险概况和物质使用结果的影响；以及5)不同物质使用之间的“门户相互作用”。Twin Hub建议使用经典和同卵双胞胎对照设计来研究遗传和环境对青少年大脑/行为发育的贡献，以及这些贡献如何预测SU倾向。使用复杂的生长轨迹建模技术，我们还将确定物质使用对大脑和行为发育的遗传和环境决定的后果，包括评估基因与环境的相互作用。此外，我们将开发生物谱系资源，用于未来可能影响物质使用及其广泛健康后果的基因组、表观基因组、代谢组学和微生物组变化的研究。具体到这个双胞胎中心，我们将从生物样本中获得基线和后续血清、唾液，在某些情况下还将获得肠道微生物区系。这项工作丰富了整个ABCD-USA联盟，因为分离G和E对个体成瘾风险的贡献和对SU的神经认知影响的敏感性具有非常重要的公共政策和基于预防的意义。