The Norwegian Mother And Child Study: Environmental Specimen Collection

挪威母子研究：环境样本收集

• 批准号: 9786010
• 负责人: Dale P Sandler
• 金额: $ 6.91万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9786010
• 关键词: Attention deficit hyperactivity disorder; Biological; Birth; Blood; Cerebral Palsy; Child; Childhood; Cohort Studies; Collaborations; Collection; DNA Methylation; Data Collection; Development; Disease; Enrollment; Environmental Exposure; Fathers; Future; Growth; Health; Infection; Measures; Medical; Metabolic; Mothers; National Institute of Environmental Health Sciences; Oral Contraceptives; Organophosphates; Outcome; Parabens; Pattern; Pesticides; Phenols; Plasma; Predisposition; Pregnancy; Protocols documentation; Publishing; Questionnaires; Reporting; Research Personnel; Risk Factors; Scientist; Serum; Specimen; System; Testing; Trace Elements; Umbilical Cord Blood; Urine; Whole Blood; Woman; base; bisphenol A; cohort; disorder risk; in utero; phthalates; sample collection

The Norwegian Mother and Child Cohort Study (MoBa) is an ongoing prebirth cohort study. Enrollment was completed in 2008 resulting in 106,980 pregnancies in the study. The study is based on questionnaires completed by the mother and father, and biological specimens are collected from the mother, father and child. The main purpose of the study is to find causes of diseases. NIEHS is providing partial support for the study, and in 2002 expanded the data collection protocol to include collection of more biologic specimens from the mothers during the 17th week of pregnancy (additional serum, a specimen of whole blood collected in a trace-element free container, and urine). These specimens will enhance the ability to examine the relation of environmental exposures in relation to various health outcomes in the children and their mothers. As of April 30, 2009, 77,104 subjects had provided blood and urine that was collected in conjunction with NIEHS. We added to the MoBa protocol the collection additional urine specimens in pregnancy, at weeks 23 and 29, for a subset of women. 690 women have a complete set of three urine specimens from pregnancy. We previously published a report about how the preservative used in the collection of the urine specimens contaminated them with free bisphenol A, and also makes the specimens difficult to analyze for other analytes such as organophosphate pesticide metabolites. This information has been useful to us in planning studies. Future studies seeking to quantitate bisphenol A will need to measure total and free BPA, so that conjuated BPA can be estimated. In collaboration with Dr. Stephanie Engel at UNC, we determined that the specimens can be analyzed for organophosphate pesticide metabolites and phthalates, and we are now collaborating with her on studies of these agents in relation to attention-deficit hyperactivity disorder in MoBa children. We also were successful in using the urines in a study of the reliability of phenolic compounds such as parabens during pregnancy. We also have studied the maternal plasma concentration of perfluoralkyl substances (PFAS) in relation to various outcomes among women in the MoBa cohort. This year we made progress on ongoing studies on PFAS exposure in relation to child growth, and in relation to infections in childhood. We also are completing projects on how use of oral contraceptives and menstrual patterns influence the plasma concentration of these compounds. Scientists at NIEHS have developed several studies that are nested within MoBa. A list of the studies currently ongoing includes: Risk factors for cerebral palsy, Determinants of DNA methylation in cord blood, and additional studies on perfluorinated compound exposure and various aspects of health.

挪威母婴队列研究 (MoBa) 是一项正在进行的产前队列研究。 该研究于 2008 年完成入组，共有 106,980 名孕妇怀孕。该研究以母亲和父亲填写的问卷为基础，并从母亲、父亲和孩子身上采集生物样本。研究的主要目的是寻找疾病的原因。 NIEHS 为这项研究提供部分支持，并于 2002 年扩大了数据收集方案，包括在怀孕第 17 周期间从母亲身上收集更多生物样本（额外的血清、在无微量元素的容器中收集的全血样本和尿液）。 这些标本将增强检查环境暴露与儿童及其母亲的各种健康结果之间关系的能力。 截至 2009 年 4 月 30 日，已有 77,104 名受试者提供了与 NIEHS 联合收集的血液和尿液。 我们在 MoBa 方案中添加了在怀孕第 23 周和第 29 周时为一部分女性收集额外尿液样本的内容。 690 名女性拥有一套完整的三份怀孕尿液样本。 我们之前发表了一份报告，介绍了收集尿液样本时使用的防腐剂如何使尿液样本受到游离双酚 A 的污染，并且使样本难以分析其他分析物，例如有机磷农药代谢物。 这些信息对我们的规划研究很有用。 未来寻求定量双酚 A 的研究将需要测量总 BPA 和游离 BPA，以便估算共轭 BPA。 我们与北卡罗来纳大学的 Stephanie Engel 博士合作，确定可以分析这些样本中的有机磷农药代谢物和邻苯二甲酸盐，现在我们正在与她合作研究这些药物与 MoBa 儿童注意力缺陷多动障碍的关系。 我们还成功地利用尿液研究了怀孕期间苯甲酸酯等酚类化合物的可靠性。 我们还研究了 MoBa 队列中女性的母体血浆全氟烷基物质 (PFAS) 浓度与各种结果的关系。 今年，我们正在进行的有关 PFAS 暴露与儿童生长和儿童感染之间关系的研究取得了进展。 我们还正在完成有关口服避孕药的使用和月经模式如何影响这些化合物的血浆浓度的项目。 NIEHS 的科学家们已经开展了几项嵌套在 MoBa 中的研究。 目前正在进行的研究包括：脑瘫的危险因素、脐带血中 DNA 甲基化的决定因素，以及关于全氟化合物暴露和健康各个方面的其他研究。

项目成果

Maternal glomerular filtration rate in pregnancy and fetal size.

• DOI: 10.1371/journal.pone.0101897
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Morken NH;Travlos GS;Wilson RE;Eggesbø M;Longnecker MP
• 通讯作者: Longnecker MP

Triclosan exposure and allergic sensitization in Norwegian children.

• DOI: 10.1111/all.12058
• 发表时间: 2013-01
• 期刊: Allergy
• 影响因子: 12.4
• 作者: Bertelsen RJ;Longnecker MP;Løvik M;Calafat AM;Carlsen KH;London SJ;Lødrup Carlsen KC
• 通讯作者: Lødrup Carlsen KC

Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity.

• DOI: 10.1007/s00125-013-2936-7
• 发表时间: 2013-08
• 期刊: DIABETOLOGIA
• 影响因子: 8.2
• 作者: Mattsson, K.;Kallen, K.;Longnecker, M. P.;Rignell-Hydbom, A.;Rylander, L.
• 通讯作者: Rylander, L.

Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women.

怀孕挪威妇女的全氟烷基物质血浆浓度的决定因素。

• DOI: 10.1016/j.envint.2012.12.014
• 发表时间: 2013-04
• 期刊: ENVIRONMENT INTERNATIONAL
• 影响因子: 11.8
• 作者: Brantsaeter, A. L.;Whitworth, K. W.;Ydersbond, T. A.;Haug, L. S.;Haugen, M.;Knutsen, H. K.;Thomsen, C.;Meltzer, H. M.;Becher, G.;Sabaredzovic, A.;Hoppin, J. A.;Eggesbo, M.;Longnecker, M. P.
• 通讯作者: Longnecker, M. P.

Levels of hexachlorobenzene (HCB) in breast milk in relation to birth weight in a Norwegian cohort.

• DOI: 10.1016/j.envres.2009.04.001
• 发表时间: 2009-07
• 期刊: ENVIRONMENTAL RESEARCH
• 影响因子: 8.3
• 作者: Eggesbo, Merete;Stigum, Hein;Longnecker, Matthew P.;Polder, Anuschka;Aldrin, Magne;Basso, Olga;Thomsen, Cathrine;Skaare, Janneche Utne;Becher, Georg;Magnus, Per
• 通讯作者: Magnus, Per