Neural Environment in Disease: Glial Responses and Neuroinflammation

疾病中的神经环境：神经胶质反应和神经炎症

• 批准号: 9763089
• 负责人: Thale Cross Jarvis
• 金额: $ 1.92万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9763089
• 关键词: Academia; Adaptive Immune System; Address; Area; Astrocytes; Autoimmune Process; Basic Science; Behavior; Blood - brain barrier anatomy; Blood Vessels; Cell physiology; Cells; Cellular biology; Central Nervous System Diseases; Cerebrovascular system; Collaborations; Colorado; Complex; Conflict (Psychology); Disease; Disease Progression; Educational workshop; Effector Cell; Environment; Etiology; Fostering; Future; Genetic; Goals; Health; Human; Image; Immune; Immune system; Industrialization; Industry; Inflammatory; Injury; Invertebrates; Knowledge; Learning; Lymphatic; Mediating; Mental disorders; Methodology; Microglia; Modeling; Nerve Degeneration; Neuraxis; Neurodegenerative Disorders; Neuroglia; Neurons; Oligodendroglia; Outcome; Participant; Pathogenesis; Peripheral; Physiological Processes; Play; Population; Process; Research; Research Personnel; Role; Scientist; Stimulus; Stroke; Techniques; Technology; Translational Research; Traumatic injury; Work; adaptive immune response; cell type; clinical implementation; clinical practice; clinical translation; glymphatic system; induced pluripotent stem cell; interest; mouse model; nervous system disorder; neuroinflammation; neuropsychiatric disorder; neurovascular unit; novel strategies; novel therapeutics; posters; relating to nervous system; repaired; response; response to injury; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neural Environment in Disease: Glial Responses and Neuroinflammation, organized by Drs. Richard Daneman, Dorothy Schafer, Michael V. Sofroniew and Vanda A. Lennon. The conference will be held in Keystone, Colorado from June 16-20, 2019. The response of the central nervous system to injury and disease is a complex physiological process that involves the coordinated actions of many different cell types. The interplay of neural cells and vascular cells along with the innate and adaptive immune systems determines the response to different injury and disease stimuli and whether the central nervous system will repair or degenerate. Understanding this complex cellular environment is essential to understanding disease pathogenesis, elucidating underlying disease etiology, and developing treatments for neurological and psychiatric diseases. The goal of this conference will be to bring together people who study different aspects of neurological diseases and facilitate the interchange of ideas necessary for identifying new mechanisms underlying complex intercellular interactions in the diseased nervous system. This will include people who study resident neural cells (neurons, astrocytes, oligodendrocytes), vascular cells (blood-brain barrier, lymphatics, glymphatics) and immune cells (microglia, innate peripheral immune cells, adaptive immune cells) in the context of a variety of neurodegenerative, neuroinflammatory, and neuropsychiatric diseases. Further, we will also attract people who implement different techniques including genetic mouse models, human iPSCs, invertebrate models, imaging, cell biology, and behavior in their research which will further facilitate exchange of ideas and foster collaboration. With the combined expertise at this conference, we will accelerate our ability to understand the complex neural response to injury and disease, which is a necessary step towards developing novel therapeutics for complex neurological diseases.

抽象的 请求支持Keystone研讨会会议，名为“疾病神经​​环境：Glial” 反应和神经炎症，由Drs组织。理查德·丹曼（Richard Daneman），多萝西·沙弗（Dorothy Schafer），迈克尔·V（Michael V.） Sofroniew和Vanda A. Lennon。会议将于2019年6月16日至20日在科罗拉多州的基斯通举行。 中枢神经系统对损伤和疾病的反应是一个复杂的生理过程 涉及许多不同细胞类型的协调作用。神经细胞和血管细胞的相互作用 与先天和适应性免疫系统一起决定对不同伤害和疾病的反应 刺激以及中枢神经系统是否会修复或退化。了解这个复杂的细胞 环境对于理解疾病发病机理，阐明潜在的疾病病因和 开发神经和精神病的治疗方法。这次会议的目标是带来 研究神经疾病的不同方面并促进思想的互换的人在一起 确定患病中复合物间相互作用的新机制所必需的 神经系统。这将包括研究居民神经细胞（神经元，星形胶质细胞， 少突胶质细胞），血管细胞（血脑屏障，淋巴结术，肾小球）和免疫细胞（小胶质细胞，，小胶质细胞 先天外周免疫细胞，适应性免疫细胞）在多种神经退行性的背景下 神经炎症和神经精神疾病。此外，我们还将吸引实施不同的人 包括遗传小鼠模型，人IPSC，无脊椎动物模型，成像，细胞生物学和包括遗传小鼠模型的技术 他们的研究中的行为将进一步促进思想的交流并促进协作。与 在本次会议上的联合专业知识，我们将加速理解复杂神经的能力 对伤害和疾病的反应，这是开发新型治疗剂的必要步骤 神经疾病。